Evidence map›Paper›PMID 32025030›Full record

ArticleNature2020

The structure of human thyroglobulin.

Francesca Coscia, Ajda Taler-Verčič, Veronica T Chang, Ludwig Sinn, Francis J O'Reilly, Thierry Izoré, Miha Renko, Imre Berger, Juri Rappsilber, Dušan Turk and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 138 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  9. Article
  10. Review
  11. Thyroid Hormone Synthesis Without Thyroglobulin.Thyroid : official journal of the American Thyroid Association · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Francesca CosciaMRC Laboratory of Molecular Biology, Cambridge, UK.
Ajda Taler-VerčičJožef Stefan Institute, Ljubljana, Slovenia.
Veronica T ChangMRC Laboratory of Molecular Biology, Cambridge, UK.
Ludwig SinnInstitute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Francis J O'ReillyInstitute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Thierry IzoréMRC Laboratory of Molecular Biology, Cambridge, UK.
Miha RenkoJožef Stefan Institute, Ljubljana, Slovenia.
Imre BergerMax Planck Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.
Juri RappsilberInstitute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Dušan TurkJožef Stefan Institute, Ljubljana, Slovenia. dusan.turk@ijs.si.
Jan LöweMRC Laboratory of Molecular Biology, Cambridge, UK. jyl@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GBTechnische Universität Berlin · DECentre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins · SIJožef Stefan Institute · SIMax Planck-Bristol Centre for Minimal Biology · GB

Funding

Medical Research Council MC_U105184326Wellcome Trust 103139Wellcome Trust 103139/Z/13/ZWellcome Trust 202754Wellcome Trust 203149
6 · The paper itself

Abstract

Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates

Indexed as

Cryoelectron MicroscopyBacterial ProteinsHEK293 CellsHumansMaltose-Binding ProteinsModels, MolecularMutationReproducibility of ResultsSolventsThyroglobulinThyroid HormonesTyrosineBacterial ProteinsMaltose-Binding ProteinsSolventsThyroglobulinThyroid HormonesTyrosine

Identifiers

PMID32025030
PMCPMC7170718
OpenAlexW3004797639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.