Evidence map›Paper›PMID 32025029›Full record

ArticleNature2020

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.

Mohammad Shahnawaz, Abhisek Mukherjee, Sandra Pritzkow, Nicolas Mendez, Prakruti Rabadia, Xiangan Liu, Bo Hu, Ann Schmeichel, Wolfgang Singer, Gang Wu and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06868628 (A Phase 2a Study to Evaluate Microglial Activation, Safety, and Clinical Effects of Foralumab Nasal in Patients With Multiple System Atrophy), which is not on this map. Cited by 470 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
470citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06868628 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 2a Study to Evaluate Microglial Activation, Safety, and Clinical Effects of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

TypeinterventionalSponsorTiziana Life Sciences LTDRan2025 to 2027Enrolled5ConditionsMultiple System AtrophyArmsForalumab Nasal
3 · Its place in the literature

Who cites it

470 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. International journal of molecular sciences · 2024
    Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

410 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Mohammad ShahnawazMitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Abhisek MukherjeeMitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Sandra Pritzkow *Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Nicolas Mendez *Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Prakruti RabadiaMitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Xiangan LiuDepartment of Microbiology and Molecular Genetics, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Bo HuDepartment of Microbiology and Molecular Genetics, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Ann SchmeichelDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Wolfgang SingerDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Gang WuDivision of Hematology, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Ah-Lim TsaiDivision of Hematology, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Hamid ShiraniDepartment of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
K Peter R NilssonDepartment of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Phillip A LowDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Claudio SotoMitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA. Claudio.Soto@uth.tmc.edu.

Funding

Studies on Diagnosis, Pathophysiology, and Treatment of Autonomic Failure in MSAP01NS044233 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MASLIAH, ELIEZER · 2003 to 2014
$12.4M
Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2009 to 2018
$11.6M
Synucleinopathies – Novel Targets in Early Diagnosis, Pathophysiology, and Therapeutic ApproachR01NS092625 · NINDS · MAYO CLINIC ROCHESTER · PI SINGER, WOLFGANG, VEMURI, PRASHANTHI · 2015 to 2025
$6.6M
Novel Carbon Nanozyme Mechanisms for Traumatic Brain InjuryR01NS094535 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HEGDE, MURALIDHAR L, KENT, THOMAS · 2015 to 2024
$4.1M
Misfolded Protein Aggregates in HIV infectionR01AG061069 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARDUINO, ROBERTO CLAUDIO, SOTO, CLAUDIO · 2018 to 2022
$3.5M
Comprehensive diagnosis of Alzheimer's disease by detection of misfolded oligomers in biological fluidsRF1AG055053 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SOTO, CLAUDIO · 2019 to 2019
$2.9M
Differential Approach to the Postural Tachycardia SyndromeK23NS075141 · NINDS · MAYO CLINIC ROCHESTER · PI SINGER, WOLFGANG · 2012 to 2016
$872k
Phase 1 Study of Autologous Mesenchymal Stem Cell in Multiple System AtrophyR01FD004789 · FDA · MAYO CLINIC ROCHESTER · PI LOW, PHILLIP A · 2014 to 2016
$600k
FDA HHS R01 FD004789NIA NIH HHS R01 AG061069NIA NIH HHS RF1 AG055053NINDS NIH HHS K23 NS075141NINDS NIH HHS P01 NS044233NINDS NIH HHS R01 NS092625NINDS NIH HHS R01 NS094535NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy

Indexed as

alpha-SynucleinAmyloidBrain ChemistryCircular DichroismEndopeptidase KHumansMultiple System AtrophyParkinson DiseaseProtein ConformationProtein DenaturationProtein FoldingSpectroscopy, Fourier Transform Infraredalpha-SynucleinAmyloidEndopeptidase K

Identifiers

PMID32025029
PMCPMC7066875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.