ArticleScientific reports2020
Pan-cancer analyses of human nuclear receptors reveal transcriptome diversity and prognostic value across cancer types.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
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- Roles of the NR2F Family in the Development, Disease, and Cancer of the Lung.Journal of developmental biology · 2024Review
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- Liver X Receptors (LXRs) in cancer-an Eagle's view on molecular insights and therapeutic opportunities.Frontiers in cell and developmental biology · 2024Review
- CCNF is a potential pancancer biomarker and immunotherapy target.Frontiers in oncology · 2023Article
- Demystifying the Functional Role of Nuclear Receptors in Esophageal Cancer.International journal of molecular sciences · 2022Review
- Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types.BMC cancer · 2022Article
- Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers.Matrix biology plus · 2022Article
- Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways.BMC genomics · 2022Article
- A gradient tree boosting and network propagation derived pan-cancer survival network of the tumor microenvironment.iScience · 2022Article
- A seven-nuclear receptor-based prognostic signature in breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Human nuclear receptors (NRs) genes have prognostic significance in hepatocellular carcinoma patients.World journal of surgical oncology · 2021Article
- Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC.Cell death & disease · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
The human nuclear receptor (NR) superfamily comprises 48 ligand-dependent transcription factors that play regulatory roles in physiology and pathophysiology. In cancer, NRs have long served as predictors of disease stratification, treatment response, and clinical outcome. The Cancer Genome Atlas (TCGA) Pan-Cancer project provides a wealth of genetic data for a large number of human cancer types. Here, we examined NR transcriptional activity in 8,526 patient samples from 33 TCGA 'Pan-Cancer' diseases and 11 'Pan-Cancer' organ systems using RNA sequencing data. The web-based Kaplan-Meier (KM) plotter tool was then used to evaluate the prognostic potential of NR gene expression in 21/33 cancer types. Although, most NRs were significantly underexpressed in cancer, NR expression (moderate to high expression levels) was predominantly restricted (46%) to specific tissues, particularly cancers representing gynecologic, urologic, and gastrointestinal 'Pan-Cancer' organ systems. Intriguingly, a relationship emerged between recurrent positive pairwise correlation of Class IV NRs in most cancers. NR expression was also revealed to play a profound effect on patient overall survival rates, with ≥5 prognostic NRs identified per cancer type. Taken together, these findings highlighted the complexity of NR transcriptional networks in cancer and identified novel therapeutic targets for specific cancer types.
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