ArticleScientific reports2020
Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Acute changes in knee cartilage and meniscus following long-distance running in habituate runners: a systematic review on studies using quantitative magnetic resonance imaging.Skeletal radiology · 2022Pooled it
- The Influence of Running on Lower Limb Cartilage: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Grading knee cartilage degeneration and meniscal injury with combined ACS-accelerated T1ρ and T2 mapping.BMC medical imaging · 2026Article
- Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics.Experimental physiology · 2026Review
- Exercise-myokine relationships in osteoarthritis.Journal of translational medicine · 2026Review
- The application of transfer learning to T1ρ MRI tibiofemoral cartilage segmentation.Journal of biomechanics · 2026Article
- Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.Osteoarthritis and cartilage open · 2025Article
- Tibial and femoral articular cartilage exhibit opposite outcomes for T1ρ and T2* relaxation times in response to acute compressive loading in healthy knees.Journal of biomechanics · 2024Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Influence of running on femoroacetabular joint bone-to-bone distances.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Imaging of joint response to exercise with MRI and PET.Skeletal radiology · 2023Review
- Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing.Magnetic resonance in medicine · 2023Article
- High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping.Magnetic resonance in medicine · 2023Article
- Quantitative assessment of normal hip cartilage in children under 9 years old by T2 mapping.Magma (New York, N.Y.) · 2022Article
- Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.Journal of biomechanics · 2022Article
- Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping.Journal of biomechanics · 2021Article
- Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.Clinical biomechanics (Bristol, Avon) · 2021Article
- The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function.Annals of biomedical engineering · 2020Article
- Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running.Orthopaedic journal of sports medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Roughly 20% of Americans run annually, yet how this exercise influences knee cartilage health is poorly understood. To address this question, quantitative magnetic resonance imaging (MRI) can be used to infer the biochemical state of cartilage. Specifically, T1rho relaxation times are inversely related to the proteoglycan concentration in cartilage. In this study, T1rho MRI was performed on the dominant knee of eight asymptomatic, male runners before, immediately after, and 24 hours after running 3 and 10 miles. Overall, (mean ± SEM) patellar, tibial, and femoral cartilage T1rho relaxation times significantly decreased immediately after running 3 (65 ± 3 ms to 62 ± 3 ms; p = 0.04) and 10 (69 ± 4 ms to 62 ± 3 ms; p < 0.001) miles. No significant differences between pre-exercise and recovery T1rho values were observed for either distance (3 mile: p = 0.8; 10 mile: p = 0.08). Percent decreases in T1rho relaxation times were significantly larger following 10 mile runs as compared to 3 mile runs (11 ± 1% vs. 4 ± 1%; p = 0.02). This data suggests that alterations to the relative proteoglycan concentration of knee cartilage due to water flow are mitigated within 24 hours of running up to 10 miles. This information may inform safe exercise and recovery protocols in asymptomatic male runners by characterizing running-induced changes in knee cartilage composition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.