Evidence map›Paper›PMID 32024855›Full record

ArticleScientific reports2020

Relative Average Look Duration and its Association with Neurophysiological Activity in Young Children with Autism Spectrum Disorder.

Dmitry Yu Isaev, Samantha Major, Michael Murias, Kimberly L H Carpenter, David Carlson, Guillermo Sapiro, Geraldine Dawson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dmitry Yu IsaevDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA. dmitry.isaev@duke.edu.
Samantha MajorDuke Center for Autism and Brain Development and Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708, USA.
Michael MuriasDuke Center for Autism and Brain Development and Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708, USA.
Kimberly L H CarpenterDuke Center for Autism and Brain Development and Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708, USA.
David CarlsonDepartment of Civil and Environmental Engineering and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, 27708, USA.ORCID http://orcid.org/0000-0003-1005-6385
Guillermo SapiroDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Geraldine DawsonDuke Center for Autism and Brain Development and Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708, USA.ORCID http://orcid.org/0000-0003-1410-2764
Duke University · USNorthwestern University · US

Funding

Recruitment and Assessment CoreP50HD093074 · NICHD · DUKE UNIVERSITY · PI Geraldine Dawson · 2017 to 2026
$27.6M
Novel Approaches to Infant Screening for ASD in Pediatric Primary CareR01MH121329 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE · 2019 to 2023
$3.9M
Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum DisorderR01MH120093 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE, SAPIRO, GUILLERMO R · 2019 to 2022
$1.6M
NICHD NIH HHS P50 HD093074NIMH NIH HHS R01 MH120093NIMH NIH HHS R01 MH121329
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is characterized by early attentional differences that often precede the hallmark symptoms of social communication impairments. Development of novel measures of attentional behaviors may lead to earlier identification of children at risk for ASD. In this work, we first introduce a behavioral measure, Relative Average Look Duration (RALD), indicating attentional preference to different stimuli, such as social versus nonsocial stimuli; and then study its association with neurophysiological activity. We show that (1) ASD and typically developing (TD) children differ in both (absolute) Average Look Duration (ALD) and RALD to stimuli during an EEG experiment, with the most pronounced differences in looking at social stimuli; and (2) associations between looking behaviors and neurophysiological activity, as measured by EEG, are different for children with ASD versus TD. Even when ASD children show attentional engagement to social content, our results suggest that their underlying brain activity is different than TD children. This study therefore introduces a new measure of social/nonsocial attentional preference in ASD and demonstrates the value of incorporating attentional variables measured simultaneously with EEG into the analysis pipeline.

Indexed as

Social BehaviorAttentionAutism Spectrum DisorderBrainChildChild, PreschoolElectroencephalographyFeasibility StudiesFemaleHumansMaleNeurologic ExaminationTime Factors

Identifiers

PMID32024855
PMCPMC7002421
OpenAlexW3004416636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.