ArticleNature communications2020
Deep tissue space-gated microscopy via acousto-optic interaction.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media.ACS photonics · 2024Article
- Tracing multiple scattering trajectories for deep optical imaging in scattering media.Nature communications · 2023Article
- Acousto-Optics: Recent Studies and Medical Applications.Biosensors · 2023Review
- Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.Scientific reports · 2020Article
- High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging.Biomedical optics express · 2020Article
- Label-free microendoscopy using a micro-needle imaging probe forBiomedical optics express · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To extend the imaging depth of high-resolution optical microscopy, various gating operations-confocal, coherence, and polarization gating-have been devised to filter out the multiply scattered wave. However, the imaging depth is still limited by the multiply scattered wave that bypasses the existing gating operations. Here, we present a space gating method, whose mechanism is independent of the existing methods and yet effective enough to complement them. Specifically, we reconstruct an image only using the ballistic wave that is acousto-optically modulated at the object plane. The space gating suppresses the multiply scattered wave by 10-100 times in a highly scattering medium, and thus enables visualization of the skeletal muscle fibers in whole-body zebrafish at 30 days post fertilization. The space gating will be an important addition to optical-resolution microscopy for achieving the ultimate imaging depth set by the detection limit of ballistic wave.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.