ArticleScience translational medicine2020
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review.Neurogenetics · 2025Pooled it
- C/EBPβ: A transcription factor associated with the irreversible progression of Alzheimer's disease.CNS neuroscience & therapeutics · 2024Pooled it
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains.Cell stem cell · 2026Article
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains.Cell stem cell · 2026Article
- Co- and Multi-Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies.Research square · 2026Article
- Understanding the genetic imperfections of Lewy body dementia.Molecular neurodegeneration · 2026Review
- Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a model of Alzheimer's disease.Disease models & mechanisms · 2026Article
- APOE4-Expressing Astrocytes Exhibit Parkinson's Disease-Related Pathology.Molecular neurobiology · 2026Article
- Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders.Nature reviews. Neuroscience · 2026Review
- Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances.Molecular neurodegeneration · 2026Review
- Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances.Molecular neurodegeneration · 2026Review
- Multi-locus genetic dosage shapes cognitive disease progression in Parkinson's patients: 15-year meta-analysis of 24 cohorts.NPJ Parkinson's disease · 2026Article
- Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson's disease.Acta neuropathologica · 2026Article
- An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer's and Parkinson's disease.GigaScience · 2026Article
- APOE genotype differentially modulates prion pathology in a mouse model.Acta neuropathologica communications · 2026Article
- Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.Acta neurologica Belgica · 2025Article
- Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies.Molecular neurodegeneration · 2025Review
- Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies.Molecular neurodegeneration · 2025Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byAPOE2020
Authors and funding
17 authors at 2 institutions in 1 country.
Albert A DavisHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA. albert.a.davis@wustl.edu holtzman@wustl.edu.ORCID 0000-0003-2042-8445
Casey E InmanHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-0313-1175
Zachary M WargelHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
Umber DubeHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0001-9324-1927
Brittany M FreebergHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-4756-5634
Alexander GalluppiHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-0788-4166
Jessica N HainesHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
Dhruva D DhavaleHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
Rebecca MillerHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-1227-5891
Fahim A ChoudhuryHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-9612-4264
Patrick M SullivanDepartment of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.ORCID 0000-0001-8402-2634
Carlos CruchagaHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-0276-2899
Joel S PerlmutterHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
Jason D UlrichHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-4743-926X
Bruno A BenitezHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-2699-3878
Paul T KotzbauerHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0001-7155-114X
David M HoltzmanHope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA. albert.a.davis@wustl.edu holtzman@wustl.edu.ORCID 0000-0002-3400-0856
Washington University in St. Louis · USDuke Medical Center · US
Funding
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2MProtein Aggregation and Neurotransmitter Deficits in Parkinson DiseaseR01NS097799 · NINDS · WASHINGTON UNIVERSITY · PI PAUL T KOTZBAUER · 2016 to 2026
$5.8MIdentification and characterization of AD risk networks using multi-dimensional "omics" dataU01AG052411 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2016 to 2020
$4.5MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MGENETIC MODIFIERS OF CEREBROSPINAL FLUID TREM2 IN ALZHEIMER'S DISEASERF1AG058501 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, PICCIO, LAURA · 2018 to 2018
$3.5MThe Familial Alzheimer Sequencing (FASe) ProjectU01AG058922 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2018 to 2022
$3.5MEffect of APOE on CNS Neurons: Role of LRPR01NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2014 to 2018
$3.0MNovel Strategies and Mechanisms to Target APOE and Alzheimer's DiseaseR01AG047644 · NIA · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2014 to 2018
$2.8MIDENTIFYING RARE VARIANTS THAT INCREASE RISK FOR ALZHEIMER'S DISEASER01AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2013 to 2017
$2.7MInvestigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3MApoE Regulation of Alpha-Synuclein Pathology in Parkinson Disease DementiaK08NS101118 · NINDS · WASHINGTON UNIVERSITY · PI DAVIS, ALBERT A · 2017 to 2021
$859kNIA NIH HHS R01 AG044546NIA NIH HHS R01 AG047644NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG052411NIA NIH HHS U01 AG058922NINDS NIH HHS K08 NS101118NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS090934NINDS NIH HHS R01 NS097799NINDS NIH HHS RF1 NS075321
Abstract
Apolipoprotein E (
Indexed as
SynucleinopathiesAnimalsApolipoprotein E4Apolipoproteins EDisease ProgressionGenotypeHumansMiceApolipoprotein E4Apolipoproteins E
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.