Evidence map›Paper›PMID 32024796›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2020

Growth differentiation factor 15 is increased in stable MS.

Andrea Amstad, Mali Coray, Corina Frick, Christian Barro, Johanna Oechtering, Michael Amann, Jörg Wischhusen, Ludwig Kappos, Yvonne Naegelin, Jens Kuhle and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. The Effect of Thyroid Function on GDF15 Levels.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrea AmstadFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Mali CorayFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Corina FrickFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Christian BarroFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Johanna OechteringFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Michael AmannFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Jörg WischhusenFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Ludwig KapposFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Yvonne NaegelinFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Jens KuhleFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.
Matthias MehlingFrom the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany. matthias.mehling@usb.ch.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess whether serum concentrations of the anti-inflammatory cytokine growth differentiation factor 15 (GDF-15) differ in patients with highly active multiple sclerosis (MS) vs patients with stable MS and healthy controls (HCs).

methodsGDF-15 concentrations were measured by ELISA in serum and CSF in a cross-sectional cohort of patients with MS, patients with other inflammatory neurologic diseases (OIND), patients with noninflammatory neurologic diseases (NIND), and healthy controls (HC). Serum GDF-15 concentrations were measured in a longitudinally sampled cohort of clinically and radiologically well-characterized patients with MS and corresponding controls.

resultsCross-sectionally measured median serum GDF-15 concentrations were significantly higher in patients with OIND (n = 42) (600 pg/mL, interquartile range [IQR] = 320-907 pg/mL) compared with HCs (n = 29) (325 pg/mL, IQR = 275-419 pg/mL;

conclusionsSerum GDF-15 concentrations are increased in patients with MS with a stable disease course. These data suggest that GDF-15 may serve as a biomarker for disease stability in MS.

Indexed as

Disease ProgressionAdolescentAdultAgedBiomarkersCross-Sectional StudiesFemaleGrowth Differentiation Factor 15HumansLongitudinal StudiesMaleMiddle AgedMultiple SclerosisYoung AdultBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15

Identifiers

PMID32024796
PMCPMC7051204
OpenAlexW3005103746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.