Evidence map›Paper›PMID 32024754›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

TIP5 primes prostate luminal cells for the oncogenic transformation mediated by

Karolina Pietrzak, Rostyslav Kuzyakiv, Ronald Simon, Marco Bolis, Dominik Bär, Rossana Aprigliano, Jean-Philippe Theurillat, Guido Sauter, Raffaella Santoro

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  9. The emerging role of ISWI chromatin remodeling complexes in cancer.Journal of experimental & clinical cancer research : CR · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Karolina PietrzakDepartment of Molecular Mechanisms of Disease, DMMD, University of Zürich, CH-8057 Zürich, Switzerland.
Rostyslav KuzyakivDepartment of Molecular Mechanisms of Disease, DMMD, University of Zürich, CH-8057 Zürich, Switzerland.
Ronald SimonInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
Marco BolisInstitute of Oncology Research, Università della Svizzera Italiana, CH-6500 Lugano, Switzerland.
Dominik BärDepartment of Molecular Mechanisms of Disease, DMMD, University of Zürich, CH-8057 Zürich, Switzerland.
Rossana ApriglianoDepartment of Molecular Mechanisms of Disease, DMMD, University of Zürich, CH-8057 Zürich, Switzerland.
Jean-Philippe TheurillatInstitute of Oncology Research, Università della Svizzera Italiana, CH-6500 Lugano, Switzerland.
Guido SauterInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
Raffaella SantoroDepartment of Molecular Mechanisms of Disease, DMMD, University of Zürich, CH-8057 Zürich, Switzerland; raffaella.santoro@dmmd.uzh.ch.ORCID 0000-0001-9894-2896
University of Zurich · CHUniversität Hamburg · DEInstitute of Oncology Research · CHSIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is the second leading cause of cancer death in men. Its clinical and molecular heterogeneities and the lack of in vitro models outline the complexity of PCa in the clinical and research settings. We established an in vitro mouse PCa model based on organoid technology that takes into account the cell of origin and the order of events. Primary PCa with deletion of the tumor suppressor gene

Indexed as

AnimalsBromodomain Containing ProteinsCarcinogenesisCell Transformation, NeoplasticChromosomal Proteins, Non-HistoneGene DeletionGene Expression Regulation, NeoplasticHumansMaleMiceMice, KnockoutProstateProstatic NeoplasmsPTEN PhosphohydrolaseBaz2a protein, mouseBromodomain Containing ProteinsChromosomal Proteins, Non-HistonePTEN PhosphohydrolasePten protein, mouseBAZ2Aorganoidsprostate cancerPTENTIP5

Identifiers

PMID32024754
PMCPMC7035629
OpenAlexW3005236924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.