Evidence map›Paper›PMID 32024712›Full record

ArticlemSphere2020

Oral and Gut Microbial Diversity and Immune Regulation in Patients with HIV on Antiretroviral Therapy.

Medini K Annavajhala, Sabrina D Khan, Sean B Sullivan, Jayesh Shah, Lauren Pass, Karolina Kister, Heather Kunen, Victor Chiang, Gwennaëlle C Monnot, Christopher L Ricupero and 7 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Salivary mycobiome alterations in HIV-infected MSM: dominance ofFrontiers in cellular and infection microbiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The Role of Yeasts in Human Health: A Review.Life (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Medini K AnnavajhalaDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Sabrina D KhanDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Sean B SullivanDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Jayesh ShahDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Lauren PassDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Karolina KisterDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Heather KunenDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Victor ChiangDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Gwennaëlle C MonnotDepartment of Dermatology, Columbia University Medical Center, New York, New York, USA.
Christopher L RicuperoDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Rebecca A MazurDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Peter GordonDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Annemieke de JongDepartment of Dermatology, Columbia University Medical Center, New York, New York, USA.
Sunil WadhwaDepartment of Orthodontics, School of Dental Medicine, Columbia University Medical Center, New York, New York, USA.
Michael T YinDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Ryan T DemmerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA au2110@cumc.columbia.edu.ORCID 0000-0002-9798-4768
Columbia University Irving Medical Center · USUniversity of Minnesota · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
Oral immune activation and alveolar bone loss in HIV-infected postmenopausal womenR01DE026924 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WADHWA, SUNIL, YIN, MICHAEL T · 2017 to 2021
$2.3M
Immune correlates of protection from Rift Valley fever virusK08AI119448 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCELROY, ANITA K · 2016 to 2019
$713k
NCATS NIH HHS TL1 TR001875NCATS NIH HHS UL1 TR001873NIAID NIH HHS K08 AI119448NIDCR NIH HHS R01 DE026924
6 · The paper itself

Abstract

Despite evidence of a chronic inflammatory phenotype in people living with HIV (PLWH) on antiretroviral therapy (ART), the role of oral microbiota in chronic immune activation has not been fully explored. We aimed to determine the relationship between oral and gut microbiome diversity and chronic systemic inflammation in ART-treated PLWH with prevalent severe periodontitis, an inflammatory condition commonly associated with HIV infection. We assessed bacterial and fungal communities at oral and gastrointestinal sites in a cohort (

Indexed as

Gastrointestinal MicrobiomeMycobiomeAnti-HIV AgentsBacteriaFemaleHIV InfectionsHumansImmunologic FactorsInflammationLinear ModelsMiddle AgedPostmenopauseRNA, Ribosomal, 16SSalivaAnti-HIV AgentsImmunologic FactorsRNA, Ribosomal, 16Santiretroviral agentsantiretroviral therapyHIVimmune dysfunctionimmune system activationmycobiomeoral microbiome

Identifiers

PMID32024712
PMCPMC7002309
OpenAlexW3004785170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.