Evidence map›Paper›PMID 32024681›Full record

ArticleCancer discovery2020

Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy.

Johannes Menzel, Joshua C Black

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

  • Comment on
    2020
5 · Who and what money

Authors and funding

2 authors.

Johannes MenzelDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-8675-6612
Joshua C BlackDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Joshua.c.black@cuanschutz.edu.

Funding

Understanding Epigenetic Regulation of Copy Number HeterogeneityR35GM128720 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Heide L. Ford · 2018 to 2026
$3.1M
NIGMS NIH HHS R35 GM128720
6 · The paper itself

Abstract

Response rates to immune checkpoint blockade (ICB) in KRAS-mutant lung adenocarcinoma remain poor. In this issue of

Indexed as

Adenocarcinoma of LungLung NeoplasmsCell Cycle ProteinsClustered Regularly Interspaced Short Palindromic RepeatsEpigenesis, GeneticHumansImmunotherapyMolecular ChaperonesProto-Oncogene Proteins p21(ras)Tumor MicroenvironmentASF1A protein, humanCell Cycle ProteinsKRAS protein, humanMolecular ChaperonesProto-Oncogene Proteins p21(ras)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.