ArticleJournal of the American Society of Nephrology : JASN2020
Estimating Urine Albumin-to-Creatinine Ratio from Protein-to-Creatinine Ratio: Development of Equations using Same-Day Measurements.
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis : An Individual Participant-Based Meta-analysis.Annals of internal medicine · 2020Pooled it
- Prediction of microalbuminuria from proteinuria in chronic kidney disease due to non-diabetic lifestyle-related diseases: comparison with diabetes.Clinical and experimental nephrology · 2021Trial
- When systems fall apart: the performance of the nursing station model in communities with populations over 2,500 peoples.International journal of circumpolar health · 2026Article
- Can urinary albumin-creatinine ratio be used as a surrogate for protein-creatinine ratio in the diagnosis and management of pediatric steroid sensitive nephrotic syndrome?Pediatric nephrology (Berlin, Germany) · 2026Article
- Association of UACR and UPCR with kidney failure: analysis of observational data in patients with rare kidney diseases.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Observational
- Article
- Kidney Function Decline in Sickle Cell Disease: Associations with Renin-Angiotensin System Inhibitors.Kidney360 · 2026Observational
- The Association of Urine Albumin to Protein Ratio With Kidney Disease Progression.Kidney medicine · 2026Article
- Heterogeneous Kidney Patterns in Diabetic Patients Following SGLT2 Inhibitor Use.Journal of Korean medical science · 2026Article
- Correlation between thyroid function and proteinuria in patients with chronic kidney disease stages 3 and 4.International urology and nephrology · 2025Observational
- How systemic racism results in poorer outcomes for First Nations, and what First Nations are doing about it: the example of kidney health.BMC health services research · 2025Article
- Gender-affirming Hormone Therapy and Changes in Kidney Function in Adults: A Retrospective Population-based Study.Kidney medicine · 2025Article
- MyACR: A Point-of-Care Medical Device for Determination of Albumin-Creatinine Ratio (uACR) in Random Urine Samples as a Marker of Nephropathy.Diagnostics (Basel, Switzerland) · 2024Article
- National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.Clinical kidney journal · 2024Article
- The Associations of Urine Albumin-Protein Ratio With Histopathologic Lesions and Clinicopathologic Diagnoses in Individuals With Kidney Disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- New marker for chronic kidney disease progression and mortality in medical-word virtual space.Scientific reports · 2024Article
- Protein Biomarkers and Major Cardiovascular Events in Older People With Advanced CKD: The European Quality (EQUAL) Study.Kidney medicine · 2024Article
- Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis.Frontiers in medicine · 2024Article
- Article
Corrections and comments
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- Commented on byAuthors' Reply.2020
- Erratum issuedErratum.2020
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrine albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) are used to measure urine protein. Recent guidelines endorse ACR use, and equations have been developed incorporating ACR to predict risk of kidney failure. For situations in which PCR only is available, having a method to estimate ACR from PCR as accurately as possible would be useful.
methodsWe used data from a population-based cohort of 47,714 adults in Alberta, Canada, who had simultaneous assessments of urine ACR and PCR. After log-transforming ACR and PCR, we used cubic splines and quantile regression to estimate the median ACR from a PCR, allowing for modification by specified covariates. On the basis of the cubic splines, we created models using linear splines to develop equations to estimate ACR from PCR. In a subcohort with eGFR<60 ml/min per 1.73 m
resultsWe found a nonlinear association between log(ACR) and log(PCR), with the implied albumin-to-protein ratio increasing from <30% in normal to mild proteinuria to about 70% in severe proteinuria, and with wider prediction intervals at lower levels. Sex was the most important modifier of the relationship between ACR and PCR, with men generally having a higher albumin-to-protein ratio. Estimates of kidney failure risk were similar using measured ACR and ACR estimated from PCR.
conclusionsWe developed equations to estimate the median ACR from a PCR, optionally including specified covariates. These equations may prove useful in certain retrospective clinical or research applications where only PCR is available.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.