Trial reportBMC oral health2020
Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial.
Trial report in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03501225 (Influence of Use of Ozonated Water in the Lower Third Molar Surgery Impacted on Pain, Swelling, Trismus, and Quality of Life.Triple Blind Randomized Clinical Trial Split Mouth), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Use of Ozonated Water in the Lower Third Molar Surgery Impacted on Pain, Swelling, Trismus, and Quality of Life.Triple Blind Randomized Clinical Trial Split Mouth
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Complementary and alternative therapies for managing postoperative pain after lower third molar surgery: a systematic review and network meta-analysis.Clinical oral investigations · 2024Pooled it
- Comparison of suture and sutureless techniques on postoperative complications after third molar surgery: a systematic review.Clinical oral investigations · 2024Pooled it
- Effect of Ringer's Lactate versus normal saline irrigation on postoperative morbidity after surgical removal of mandibular impacted third molars: a randomized split-mouth clinical trial.BMC oral health · 2026Trial
- Clinical effects of two ozone therapy administration methods following mandibular third molar extraction: a parallel-group randomized clinical trial with exploratory salivary biomarker assessment.Clinical oral investigations · 2026Trial
- Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial.Clinical oral investigations · 2025Trial
- Ozonated water to treat pericoronitis - insights from a randomized triple-blind pilot trial.BMC oral health · 2025Trial
- Hydrogen water versus normal saline for post-surgical irrigation: A study on healing and complication rates after third molar extraction.Bioinformation · 2025Article
- Topical-Ozonized Olive Oil - A Boon for Post-Extraction Cases: A Randomized Controlled Trial.Cureus · 2023Article
- Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application.Biology · 2021Article
- Comparison of efficacy of ozonated water, normal saline, and povidone-iodine after surgical removal of impacted mandibular third molars: A cross-sectional study.Journal of family medicine and primary care · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted.
methodsPatients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect.
resultsIt was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29).
conclusionsIt was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar.
trial registrationThis clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.
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