ArticleBMC genomics2020
Comparative transcriptome analysis uncovers regulatory roles of long non-coding RNAs involved in resistance to powdery mildew in melon.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
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- Emerging roles and mechanisms of lncRNAs in fruit and vegetables.Horticulture research · 2024Review
- Epigenetic weapons of plants against fungal pathogens.BMC plant biology · 2024Review
- Integrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis.BMC genomics · 2023Article
- Whole-transcriptome analyses identify key differentially expressed mRNAs, lncRNAs, and miRNAs associated with male sterility in watermelon.Frontiers in plant science · 2023Article
- Role of long non-coding RNA in regulatory network response toFrontiers in plant science · 2023Article
- Long Non-Coding RNAs: New Players in Plants.International journal of molecular sciences · 2022Review
- Genome-Wide Identification of Powdery Mildew Responsive Long Non-Coding RNAs inFrontiers in genetics · 2022Article
- Long Noncoding RNA Expression Rofiles Elucidate the Potential Roles of lncRNA- XR_003496198 in Duck Hepatitis A Virus Type 1 Infection.Frontiers in cellular and infection microbiology · 2022Article
- Genome wide identification of lncRNAs and circRNAs having regulatory role in fruit shelf life in health crop cucumber (Frontiers in plant science · 2022Article
- Global identification of long non-coding RNAs involved in the induction of spinach flowering.BMC genomics · 2021Article
- Waterlogging-Stress-Responsive LncRNAs, Their Regulatory Relationships with miRNAs and Target Genes in Cucumber (International journal of molecular sciences · 2021Article
- Mutation of a major CG methylase alters genome-wide lncRNA expression in rice.G3 (Bethesda, Md.) · 2021Article
- miRNA Mediated Regulation and Interaction between Plants and Pathogens.International journal of molecular sciences · 2021Review
- Identification of long noncoding RNAs involved in resistance to downy mildew in Chinese cabbage.Horticulture research · 2021Article
- Interplay between miRNAs and lncRNAs: Mode of action and biological roles in plant development and stress adaptation.Computational and structural biotechnology journal · 2021Review
- Molecular Breeding Strategy and Challenges Towards Improvement of Downy Mildew Resistance in Cauliflower (Frontiers in plant science · 2021Review
- The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress.International journal of molecular sciences · 2020Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLong non-coding RNAs (lncRNAs) are a class of non-coding RNAs with more than 200 nucleotides in length, which play vital roles in a wide range of biological processes. Powdery mildew disease (PM) has become a major threat to the production of melon. To investigate the potential roles of lncRNAs in resisting to PM in melon, it is necessary to identify lncRNAs and uncover their molecular functions. In this study, we compared the lncRNAs between a resistant and a susceptible melon in response to PM infection.
resultsIt is reported that 11,612 lncRNAs were discovered, which were distributed across all 12 melon chromosomes, and > 85% were from intergenic regions. The melon lncRNAs have shorter transcript lengths and fewer exon numbers than protein-coding genes. In addition, a total of 407 and 611 lncRNAs were found to be differentially expressed after PM infection in PM-susceptible and PM-resistant melons, respectively. Furthermore, 1232 putative targets of differently expressed lncRNAs (DELs) were discovered and gene ontology enrichment (GO) analysis showed that these target genes were mainly enriched in stress-related terms. Consequently, co-expression patterns between LNC_018800 and CmWRKY21, LNC_018062 and MELO3C015771 (glutathione reductase coding gene), LNC_014937 and CmMLO5 were confirmed by qRT-PCR. Moreover, we also identified 24 lncRNAs that act as microRNA (miRNA) precursors, 43 lncRNAs as potential targets of 22 miRNA families and 13 lncRNAs as endogenous target mimics (eTMs) for 11 miRNAs.
conclusionThis study shows the first characterization of lncRNAs involved in PM resistance in melon and provides a starting point for further investigation into the functions and regulatory mechanisms of lncRNAs in the resistance to PM.
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