ArticleClinical and experimental pediatrics2020
Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study.
Article in Clinical and experimental pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review).Molecular medicine reports · 2026Review
- Effect of Breastfeeding on the Course of Respiratory Syncytial Virus Infection in Infants: A Single-Center Retrospective Study.Pediatric reports · 2025Article
- Call to include breastfeeding as a synergistic approach to vaccines for prevention of respiratory syncytial virus disease.International breastfeeding journal · 2025Article
- Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis.Clinical and experimental pediatrics · 2024Article
- Healthcare resource utilisation and costs in infants with confirmed respiratory syncytial virus infections: a national population cohort study.BMC infectious diseases · 2024Article
- Analysis of BeyfortusCurrent issues in molecular biology · 2024Review
- Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome.Diseases (Basel, Switzerland) · 2024Article
- The Current Status of Prolonged Breastfeeding and Its Related Factors in Korean Infants and Their Mothers: A Nationwide Cross-Sectional Study.Journal of Korean medical science · 2023Article
- Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children.Viruses · 2023Article
- Case-control study of exclusive breast feeding and severe bronchiolitis in the United States.Paediatric and perinatal epidemiology · 2023Article
- Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding.PloS one · 2023Article
- Altered intestinal microbiota in children with bronchiolitis.Frontiers in microbiology · 2023Article
- Maternal Immunization Using a Protein Subunit Vaccine Mediates Passive Immunity againstViruses · 2022Article
- Clinical importance of immunonutrition in infants: a review of the recent literature.Clinical and experimental pediatrics · 2022Article
- Exclusive Breastfeeding and Vitamin D Supplementation: A Positive Synergistic Effect on Prevention of Childhood Infections?International journal of environmental research and public health · 2022Review
- Early-Life Lung and Gut Microbiota Development and Respiratory Syncytial Virus Infection.Frontiers in immunology · 2022Review
- BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women.Nature communications · 2021Article
- Breastmilk Feeding during the First 4 to 6 Months of Age and Childhood Disease Burden until 10 Years of Age.Nutrients · 2021Article
- Appropriate care for neonates born to mothers with COVID-19 disease.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBreastfeeding reportedly reduces the overall frequency of infections. Respiratory syncytial virus (RSV), the most common respiratory pathogen in infants, involves recurrent wheezing and has a pathogenic mechanism related to airway structural damage. PURPOSE: This study aimed to investigate whether breastfeeding has a beneficial effect against RSV-induced respiratory infection compared to formula feeding among infants in Korea.
methodsWe retrospectively reviewed the medical records of infants under 1 year of age who were admitted with RSV infection between January 2016 and February 2018 at the department of pediatrics of 4 hospitals. We investigated the differences in clinical parameters such as cyanosis, chest retraction, combined infection, fever duration, oxygen use, oxygen therapy duration, intensive care unit (ICU) admission, and corticosteroid treatment of exclusive breast milk feeding (BMF), artificial milk formula fed (AMF), and mixed feeding (MF) groups.
resultsAmong the 411 infants included in our study, 94, 161, and 156 were included in the BMF, MF, and AMF groups, respectively. The rates of oxygen therapy were significantly different among the BMF (4.3%), MF (8.1%), and AMF (13.5 %) groups (P=0.042). The odds ratios (ORs) for oxygen therapy was significantly higher in the AMF group than in the BMF group (adjusted OR, 3.807; 95% confidence interval, 1.22-11.90; P=0.021). The ICU admission rate of the BMF group (1.1%) was lower than that of the MF (3.5%) and AMF (4.5%) groups; however, the dissimilarity was not statistically significant (P=0.338).
conclusionThe severity of RSV infection requiring oxygen therapy was lower in the BMF than the AMF group. This protective role of human milk on RSV infection might decrease the need for oxygen therapy suggesting less airway damage.
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Registered trials
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