Evidence map›Paper›PMID 32024212›Full record

ArticleVaccines2020

Protective Immunity Elicited by VP1 Chimeric Antigens of Bacterial Ghosts against Hand-Foot-and-Mouth Disease Virus.

Saisai Gong, Nan Nan, Yakun Sun, Zhili He, Jiajia Li, Fanghong Chen, Tao Li, Nianzhi Ning, Jianxin Wang, Zhan Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Comparison of the immune effects of theFrontiers in microbiology · 2024
    Article
  6. Review
  7. Efficient Robust Yield Method for Preparing Bacterial Ghosts byBioengineering (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Saisai GongState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Nan NanState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Yakun SunState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Zhili HeState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Jiajia LiState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Fanghong ChenState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Tao LiState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Nianzhi NingState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Jianxin WangState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Zhan LiState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Deyan LuoState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Hui WangState Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, China.
Institute of Microbiology · CNAnhui Medical University · CN

Funding

National Key Lab Research program SKLPBS1811National Key Research Project 2018ZX10101003-005-001National Natural Science Foundation of China 31870156
6 · The paper itself

Abstract

This study was designed to evaluate the immunogenicity and protective efficacy of two VP1 chimeric antigens of bacterial ghosts. Inoculation of the two VP1 chimeric antigens of bacterial ghosts into BALB/c mice markedly elicited humoral and mucosal immune responses. The specific antibodies induced by the chimeric ghosts protected mice not only against the virus that causes hand-foot-and-mouth disease but also against

Indexed as

bacterial ghostCoxsackie virusenterovirus 71hand, foot, and mouth disease

Identifiers

PMID32024212
PMCPMC7158693
OpenAlexW3035152609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.