ArticleMaterials (Basel, Switzerland)2020
Mechanobiological Approach to Design and Optimize Bone Tissue Scaffolds 3D Printed with Fused Deposition Modeling: A Feasibility Study.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Finite element analysis of primary healing implants with different transmucosal designs.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026Article
- Fabrication and evaluation of a host-guest polylactic acid/gelatin-hydroxyapatite-blueberry scaffold for bone regeneration.Journal of orthopaedic surgery and research · 2025Article
- Finite Element Analysis of Implant Stability Quotient (ISQ) and Bone Stresses for Implant Inclinations of 0°, 15°, and 20°.Materials (Basel, Switzerland) · 2025Article
- Article
- Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue Engineering in Endocrine, Metabolic and Immune Disorders.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes.Journal of functional biomaterials · 2023Review
- Customized Additive Manufacturing in Bone Scaffolds-The Gateway to Precise Bone Defect Treatment.Research (Washington, D.C.) · 2023Review
- 3D-Printing Graphene Scaffolds for Bone Tissue Engineering.Pharmaceutics · 2022Review
- Hybprinting for musculoskeletal tissue engineering.iScience · 2022Review
- A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Design of Materials for Bone Tissue Scaffolds.Materials (Basel, Switzerland) · 2021Article
- Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.Biomechanics and modeling in mechanobiology · 2021Article
- Powder Loading Effects on the Physicochemical and Mechanical Properties of 3D Printed Poly Lactic Acid/Hydroxyapatite Biocomposites.International journal of bioprinting · 2021Article
- Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes.Materials (Basel, Switzerland) · 2020Article
- An Algorithm to Optimize the Micro-Geometrical Dimensions of Scaffolds with Spherical Pores.Materials (Basel, Switzerland) · 2020Article
- Challenges on optimization of 3D-printed bone scaffolds.Biomedical engineering online · 2020Review
- The Possibility of Interlocking Nail Fabrication from FFF 3D Printing PLA/PCL/HA Composites Coated by Local Silk Fibroin for Canine Bone Fracture Treatment.Materials (Basel, Switzerland) · 2020Article
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Authors and funding
6 authors.
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Abstract
In spite of the rather large use of the fused deposition modeling (FDM) technique for the fabrication of scaffolds, no studies are reported in the literature that optimize the geometry of such scaffold types based on mechanobiological criteria. We implemented a mechanobiology-based optimization algorithm to determine the optimal distance between the strands in cylindrical scaffolds subjected to compression. The optimized scaffolds were then 3D printed with the FDM technique and successively measured. We found that the difference between the optimized distances and the average measured ones never exceeded 8.27% of the optimized distance. However, we found that large fabrication errors are made on the filament diameter when the filament diameter to be realized differs significantly with respect to the diameter of the nozzle utilized for the extrusion. This feasibility study demonstrated that the FDM technique is suitable to build accurate scaffold samples only in the cases where the strand diameter is close to the nozzle diameter. Conversely, when a large difference exists, large fabrication errors can be committed on the diameter of the filaments. In general, the scaffolds realized with the FDM technique were predicted to stimulate the formation of amounts of bone smaller than those that can be obtained with other regular beam-based scaffolds.
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