Evidence map›Paper›PMID 32023816›Full record

ArticleInternational journal of molecular sciences2020

Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury.

Piera Filomena Fiore, Anna Benedetti, Martina Sandonà, Luca Madaro, Marco De Bardi, Valentina Saccone, Pier Lorenzo Puri, Cesare Gargioli, Biliana Lozanoska-Ochser, Marina Bouché

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Accelerating theLife (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Targeting PKCθ Promotes Satellite Cell Self-Renewal.International journal of molecular sciences · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Piera Filomena FioreDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Anna BenedettiDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Martina SandonàDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Luca MadaroDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Marco De BardiIRCCS Fondazione Santa Lucia (FSL), 00143 Rome, Italy.
Valentina SacconeIRCCS Fondazione Santa Lucia (FSL), 00143 Rome, Italy.
Pier Lorenzo PuriDevelopment, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Cesare GargioliDepartment of Biology, Tor Vergata University, 00133 Rome, Italy.
Biliana Lozanoska-OchserDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Marina BouchéDepartment of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.
Sapienza University of Rome · ITFondazione Santa Lucia · ITSanford Burnham Prebys Medical Discovery Institute · USUniversità Cattolica del Sacro Cuore · ITUniversity of Rome Tor Vergata · IT

Funding

Fondazione Telethon GGP13233
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a genetic disease characterized by muscle wasting and chronic inflammation, leading to impaired satellite cells (SCs) function and exhaustion of their regenerative capacity. We previously showed that lack of PKCθ in

Indexed as

AnimalsCardiotoxinsCell DifferentiationCells, CulturedMaleMiceMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, DuchennePAX7 Transcription FactorProtein Kinase C-thetaReceptor, Notch1RegenerationSignal TransductionStem CellsStem Cell TransplantationCardiotoxinsNotch1 protein, mousePax7 protein, mousePAX7 Transcription FactorPrkcq protein, mouseProtein Kinase C-thetaReceptor, Notch1Duchenne Muscular Dystrophymdxmuscle satellite cellsProtein Kinase C θ

Identifiers

PMID32023816
PMCPMC7037041
OpenAlexW3004345714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.