Evidence map›Paper›PMID 32023584›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Head and Neck Paraganglioma Atypically Carrying a Succinate Dehydrogenase Subunit B Mutation (L157X).

Ken Takeshima, Hiroyuki Ariyasu, Shinsuke Uraki, Chie Kitahara, Shuhei Morita, Hidefumi Inaba, Hiroshi Iwakura, Kenji Warigaya, Shin-Ichi Murata, Yuto Yamazaki and 2 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ken TakeshimaFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Hiroyuki AriyasuFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Shinsuke UrakiFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Chie KitaharaDepartment of Pathology, Tohoku University Graduate School of Medicine, Japan.
Shuhei MoritaFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Hidefumi InabaFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Hiroshi IwakuraFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Kenji WarigayaDepartment of Human Pathology, Wakayama Medical University, Japan.
Shin-Ichi MurataDepartment of Human Pathology, Wakayama Medical University, Japan.
Yuto YamazakiDepartment of Pathology, Tohoku University Graduate School of Medicine, Japan.
Hironobu SasanoDepartment of Pathology, Tohoku University Graduate School of Medicine, Japan.
Takashi AkamizuFirst Department of Internal Medicine, Wakayama Medical University, Japan.
Wakayama Medical University · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 53-year-old woman was admitted to a hospital for gradual left-ear hearing loss over 2 years. Head computed tomography revealed a 2-cm mass along the left jugular bulb and another at the right carotid bulb. The right tumor was resected; the pathological diagnosis was carotid body paraganglioma. Mutations of succinate dehydrogenase (SDH) were suspected, but SDHB staining remained in the tumor. Genetic testing identified a known SDHB mutation (L157X). The patient had head and neck paraganglioma with an SDHB mutation (L157X) more typical of an SDHD mutation. SDHB immunohistochemistry is useful for detecting SDHx mutations, but careful interpretation is needed.

Indexed as

Carotid Body TumorDiagnosis, DifferentialFemaleGerm-Line MutationHead and Neck NeoplasmsHearing LossHumansMiddle AgedSuccinate DehydrogenaseSDHD protein, humanSuccinate Dehydrogenasebrown adipose tissuehead and neck paragangliomaL157Xparagangliomapositron emission tomographysuccinate dehydrogenase

Identifiers

PMID32023584
PMCPMC7270757
OpenAlexW3005396568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.