Evidence map›Paper›PMID 32023444›Full record

ArticleCell metabolism2020

A Nervous Breakdown that May Stop Autoimmune Diabetes.

Madina Makhmutova, Rayner Rodriguez-Diaz, Alejandro Caicedo

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Madina MakhmutovaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Rayner Rodriguez-DiazDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Alejandro CaicedoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Molecular Cell and Developmental Biology Program, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: acaicedo@med.miami.edu.
University of Miami · US

Funding

In situ analysis of functional endocrine, vascular, and immune cell interactions during early postnatal development of the human pancreasU01DK120456 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BRISSOVA, MARCELA, CAICEDO, ALEJANDRO · 2018 to 2021
$2.6M
The delta cell as a key regulator of pancreatic islet biologyR01DK124527 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RODRIGUEZ-DIAZ, RAYNER · 2020 to 2024
$1.9M
The Role of Innervation for Hormone Secretion in Human IsletsR01DK084321 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2011 to 2015
$1.8M
Harnessing Innervation to Promote Pancreatic Islet FunctionR01DK113093 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2017 to 2020
$1.5M
Cholinergic signaling in the human pancreatic isletR01DK111538 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2016 to 2018
$1.2M
Imaging mitochondrial signaling in B-cells ectopically implanted in the eyeR33ES025673 · NIEHS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO, MORAES, CARLOS TORRES · 2018 to 2019
$761k
The role of the delta cell in islet homeostasisR21DK114418 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RODRIGUEZ-DIAZ, RAYNER · 2017 to 2019
$576k
Imaging mitochondrial signaling in B-cells ectopically implanted in the eyeR21ES025673 · NIEHS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO, MORAES, CARLOS TORRES · 2015 to 2017
$569k
Autonomic Sensory Innervation of the Pancreatic Islet of LangerhansF31DK112596 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SOKOLOV, MADINA MAKHMUTOVA · 2016 to 2019
$133k
NIDDK NIH HHS F31 DK112596NIDDK NIH HHS R01 DK084321NIDDK NIH HHS R01 DK111538NIDDK NIH HHS R01 DK113093NIDDK NIH HHS R01 DK124527NIDDK NIH HHS R21 DK114418NIDDK NIH HHS U01 DK120456NIEHS NIH HHS R21 ES025673NIEHS NIH HHS R33 ES025673
6 · The paper itself

Abstract

Neuromodulation is a promising new therapeutic avenue to treat chronic diseases. A paper that appeared recently in Nature Biotechnology (Guyot et al., 2019) now provides a roadmap for how to establish electrostimulation of nerves to delay or even prevent type 1 diabetes.

Indexed as

Diabetes Mellitus, Type 1Electric Stimulation TherapyHumans

Identifiers

PMID32023444
PMCPMC7477910
OpenAlexW3005080878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.