Trial reportJournal of neural engineering2020
Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.
Trial report in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Speech motor cortex enables BCI cursor control and click.Journal of neural engineering · 2025Trial
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- Intracortical BCI Performance is Robust to Changes in Attentional Load During Dual-Tasking.bioRxiv : the preprint server for biology · 2026Article
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Speech motor cortex enables BCI cursor control and click.bioRxiv : the preprint server for biology · 2024Article
- An Accurate and Rapidly Calibrating Speech Neuroprosthesis.The New England journal of medicine · 2024Article
- An accurate and rapidly calibrating speech neuroprosthesis.medRxiv : the preprint server for health sciences · 2024Article
- Brain-Computer Interfaces with Intracortical Implants for Motor and Communication Functions Compensation: Review of Recent Developments.Sovremennye tekhnologii v meditsine · 2024Review
- A motor association area in the depths of the central sulcus.Nature neuroscience · 2023Article
- Validation of a non-invasive, real-time, human-in-the-loop model of intracortical brain-computer interfaces.Journal of neural engineering · 2022Article
- Dataset of Speech Production in intracranial.Electroencephalography.Scientific data · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
- Article
- Real-time synthesis of imagined speech processes from minimally invasive recordings of neural activity.Communications biology · 2021Article
- Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia.IEEE transactions on bio-medical engineering · 2021Article
- Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus.Journal of neural engineering · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSpeech-related neural modulation was recently reported in 'arm/hand' area of human dorsal motor cortex that is used as a signal source for intracortical brain-computer interfaces (iBCIs). This raises the concern that speech-related modulation might deleteriously affect the decoding of arm movement intentions, for instance by affecting velocity command outputs. This study sought to clarify whether or not speaking would interfere with ongoing iBCI use. APPROACH: A participant in the BrainGate2 iBCI clinical trial used an iBCI to control a computer cursor; spoke short words in a stand-alone speech task; and spoke short words during ongoing iBCI use. We examined neural activity in all three behaviors and compared iBCI performance with and without concurrent speech. MAIN
resultsDorsal motor cortex firing rates modulated strongly during stand-alone speech, but this activity was largely attenuated when speaking occurred during iBCI cursor control using attempted arm movements. 'Decoder-potent' projections of the attenuated speech-related neural activity were small, explaining why cursor task performance was similar between iBCI use with and without concurrent speaking. SIGNIFICANCE: These findings indicate that speaking does not directly interfere with iBCIs that decode attempted arm movements. This suggests that patients who are able to speak will be able to use motor cortical-driven computer interfaces or prostheses without needing to forgo speaking while using these devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.