Evidence map›Paper›PMID 32023009›Full record

ArticleCancer medicine2020

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR-760/SOCS3 pathway.

Li Li, Poling Yu, Ping Zhang, Huanmei Wu, Qizhen Chen, Shuangdi Li, Yanqiu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Effects of Circ_0109046 Regulating Mir-338-3p on the Malignant Behavior of A2780 Cells.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. The Roles of circMTO1 in Cancer.Frontiers in cell and developmental biology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Li LiDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Poling YuDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei, Taiwan, China.
Ping ZhangDepartment of Reproductive Medicine, Linyi People's Hospital, Linyi City, China.
Huanmei WuDepartment of BioHealth Informatics, School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.
Qizhen ChenDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Shuangdi LiDepartment of Gynecology, Shanghai First maternity and infant Hospital, Shanghai, China.
Yanqiu WangReproductive Medical Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0002-6688-7850
Tongji University · CNLinyi People's Hospital · CNNational Yang Ming Chiao Tung University · TWShanghai First Maternity and Infant Hospital · CNUniversity of Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OVA) is a fatal and common malignancy in women worldwide. Circular RNAs (circRNAs) consist of a family of circular endogenous RNAs generated by selective splicing, and they are involved in many diseases. Previous studies reported that hsa_circ_0007874 is aberrantly expressed in cancer and functions in tumorigenesis. While the hsa_circ_0007874 role in OVA is unclear. Here, we detected the hsa_circ_0007874 expression in OVA cell lines using Rt-qPCR. Hsa_circ_0007874 subcellular localization was confirmed by fluorescence in situ hybridization. The relationship between hsa_circ_0007874, microRNAs (miRNAs), and relative protein levels was assessed using the luciferase reporter assays. Results verified that hsa_circ_0007874 is downregulated in OVA cell lines. hsa_circ_0007874 overexpression decreased the OVA cell migration and proliferation in vitro and in vivo. Bioinformatics and luciferase reporter assays confirmed that miR-760 and SOCS3 are the downstream targets of hsa_circ_0007874. Downregulation of SOCS3 or miR-760 overexpression restored the migration and proliferation ability of SKOV3 or A2780 cells overexpressing hsa_circ_0007874. Downregulation of SOCS3 restored the proliferation and migration in miR-760 knockdown SKOV3 and A2780 cells. In summary, the data suggest that hsa_circ_0007874 acts as a tumor suppressor by regulating the miR-760/SOCS3 axis, highlighting its potential as an effective therapeutic target for OVA.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorCell MovementCell ProliferationDisease ProgressionFemaleHumansMiceMice, Inbred BALB CMice, NudeMicroRNAsOvarian NeoplasmsRNA, CircularSuppressor of Cytokine Signaling 3 ProteinBiomarkers, TumorMicroRNAsMIRN760 microRNA, humanRNA, CircularSOCS3 protein, humanSuppressor of Cytokine Signaling 3 Proteinhsa_circ_0007874miR-760ovarian cancerSOCS3

Identifiers

PMID32023009
PMCPMC7131836
OpenAlexW3004750443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.