Evidence map›Paper›PMID 32022587›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and CO

Angela Fago, Chandrasekhar Natarajan, Martín Pettinati, Federico G Hoffmann, Tobias Wang, Roy E Weber, Salvador I Drusin, Federico Issoglio, Marcelo A Martí, Darío Estrin and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Changes in hemoglobin function and isoform expression during embryonic development in the American alligator,American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  5. Article
  6. Article
  7. Synthesis of Recombinant Human Hemoglobin With NHCurrent protocols in protein science · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Angela FagoZoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-7315-2628
Chandrasekhar NatarajanSchool of Biological Sciences, University of Nebraska, Lincoln, Nebraska.ORCID 0000-0002-4841-0426
Martín PettinatiDepartamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-8849-2948
Federico G HoffmannDepartment of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, Mississippi.ORCID 0000-0001-5056-4929
Tobias WangZoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-4350-3682
Roy E WeberZoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-6865-441X
Salvador I DrusinDepartmento de Química Biolόgica/IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0001-5350-514X
Federico IssoglioDepartmento de Química Biolόgica/IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0001-9225-7855
Marcelo A MartíDepartmento de Química Biolόgica/IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-7911-9340
Darío EstrinDepartamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-5006-7225
Jay F StorzSchool of Biological Sciences, University of Nebraska, Lincoln, Nebraska.ORCID 0000-0001-5448-7924
Consejo Nacional de Investigaciones Científicas y Técnicas · ARAarhus University · DKUniversity of Nebraska–Lincoln · USBiocom · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Mutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5M
NHLBI NIH HHS R01 HL087216NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Hemoglobins (Hbs) of crocodilians are reportedly characterized by unique mechanisms of allosteric regulatory control, but there are conflicting reports regarding the importance of different effectors, such as chloride ions, organic phosphates, and CO

Indexed as

Adenosine TriphosphateAllosteric RegulationAmino Acid SequenceAnimalsCarbon DioxideChloridesHemoglobinsOxygenTemperatureAdenosine TriphosphateCarbon DioxideChloridesHemoglobinsOxygenadaptationallosterybloodoxygen transportreptile

Identifiers

PMID32022587
PMCPMC7099459
OpenAlexW3005462056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.