Evidence map›Paper›PMID 32022543›Full record

ArticleBiochemistry2020

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.

Di Zhang, Brandon E Burdette, Zhengyu Wang, Kumari Karn, Hong-Yu Li, Vern L Schramm, Peter C Tyler, Gary B Evans, Shanzhi Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Di ZhangCollege of Animal Science and Technology , Jilin Agricultural University , Changchun 130118 , China.
Brandon E BurdetteDepartment of Chemistry , University of Arkansas at Little Rock , Little Rock , Arkansas 72204 , United States.
Zhengyu WangDepartment of Pharmaceutical Sciences , University of Arkansas for Medical Science , Little Rock , Arkansas 72205 , United States.
Kumari KarnDepartment of Chemistry , University of Arkansas at Little Rock , Little Rock , Arkansas 72204 , United States.
Hong-Yu LiDepartment of Pharmaceutical Sciences , University of Arkansas for Medical Science , Little Rock , Arkansas 72205 , United States.ORCID 0000-0001-9212-2010
Vern L SchrammDepartment of Biochemistry , Albert Einstein College of Medicine , New York , New York 10461 , United States.ORCID 0000-0002-8056-1929
Peter C TylerFerrier Research Institute , Victoria University of Wellington , Wellington 5040 , New Zealand.ORCID 0000-0002-3151-6208
Gary B EvansFerrier Research Institute , Victoria University of Wellington , Wellington 5040 , New Zealand.
Shanzhi WangDepartment of Chemistry , University of Arkansas at Little Rock , Little Rock , Arkansas 72204 , United States.ORCID 0000-0002-7068-0756
University of Arkansas at Little Rock · USUniversity of Arkansas for Medical Sciences · USVictoria University of Wellington · NZAlbert Einstein College of Medicine · US

Funding

TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR01GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1989 to 2023
$10.0M
Selective RET Kinase and Its Mutant Inhibitors for the Treatment of Medullary Thyroid CancerR01CA197178 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI LI, HONG-YU, MCDONALD, NEIL · 2015 to 2019
$1.5M
NCI NIH HHS R01 CA197178NIGMS NIH HHS R01 GM041916
6 · The paper itself

Abstract

Transition state analogue inhibitor design (TSID) and fragment-based drug design (FBDD) are drug design approaches typically used independently. Methylthio-DADMe-Immucillin-A (MTDIA) is a tight-binding transition state analogue of bacterial 5'-methylthioadenosine nucleosidases (MTANs). Previously,

Indexed as

AdenineBacteriaBacterial ProteinsCatalytic DomainEnzyme InhibitorsPolyethylene GlycolsProtein BindingPurine-Nucleoside PhosphorylasePyrrolidines5'-methylthioadenosine phosphorylaseAdenineBacterial ProteinsEnzyme Inhibitorsmethylthio-DADMe-immucillin-APolyethylene GlycolsPurine-Nucleoside PhosphorylasePyrrolidines

Identifiers

PMID32022543
PMCPMC10644263
OpenAlexW3005050488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.