Evidence map›Paper›PMID 32022457›Full record

ArticleChemMedChem2020

Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.

Austin J Leitgeb, Javier A Feliciano, Hugo A Sanchez, Ryan A Allen, Kelly R Morrison, Kyle J Sommers, Robert G Carden, William M Wuest, Kevin P C Minbiole

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Austin J LeitgebDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.
Javier A FelicianoDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.
Hugo A SanchezDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.
Ryan A AllenDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Kelly R MorrisonDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Kyle J SommersDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.
Robert G CardenDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.ORCID 0000-0002-4513-8244
William M WuestDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Kevin P C MinbioleDepartment of Chemistry, Villanova University, Villanova, PA, 19085, USA.

Funding

Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
NIGMS NIH HHS R35 GM119426
6 · The paper itself

Abstract

Thirty-six biscationic quaternary ammonium compounds were efficiently synthesized in one step to examine the effect of molecular geometry of two-carbon linkers on antimicrobial activity. The synthesized compounds showed strong antimicrobial activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). While the linker geometry showed only a modest correlation with antimicrobial activity, several of the synthesized bisQACs are promising potential antiseptics due to good antimicrobial activity (MIC≤2 μM) and their higher therapeutic indices compared to previously reported QACs.

Indexed as

Anti-Bacterial AgentsDose-Response Relationship, DrugGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular StructureQuaternary Ammonium CompoundsSurface-Active AgentsAnti-Bacterial AgentsQuaternary Ammonium CompoundsSurface-Active AgentsantisepticsbisQACsmethicillin-resistant Staphylococcus aureus (MRSA)quaternary ammonium compounds

Identifiers

PMID32022457
PMCPMC8322965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.