ArticleMagnetic resonance in medicine2020
Diffusion-time dependence of diffusional kurtosis in the mouse brain.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
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- Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI.Frontiers in neuroscience · 2026Article
- Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.Acta neuropathologica communications · 2025Article
- Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025Review
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- Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue.NMR in biomedicine · 2025Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- Revealing membrane integrity and cell size from diffusion kurtosis time dependence.Magnetic resonance in medicine · 2025Article
- Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.Magnetic resonance in medicine · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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- Diffusional kurtosis time dependence and the water exchange rate for the multi-compartment Kärger model.Magnetic resonance in medicine · 2024Article
- Restricted diffusion characteristics in oscillating gradient spin echo with mesoscopic phantom.Heliyon · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate diffusion-time dependency of diffusional kurtosis in the mouse brain using pulsed-gradient spin-echo (PGSE) and oscillating-gradient spin-echo (OGSE) sequences.
methods3D PGSE and OGSE kurtosis tensor data were acquired from ex vivo brains of adult, cuprizone-treated, and age-matched control mice with diffusion-time (t
resultsKurtosis and diffusivity maps exhibited significant region-specific changes with diffusion time/frequency across both gray and white matter areas. PGSE- and OGSE-based kurtosis maps showed reversed contrast between gray matter regions in the cerebellar and cerebral cortex. Localized time/frequency-dependent changes in kurtosis tensor metrics were found in the splenium of the corpus callosum in cuprizone-treated mouse brains, corresponding to regional demyelination seen with histological assessment. Monte Carlo simulations showed that kurtosis estimates with pulsed- and oscillating-gradient waveforms differ in their sensitivity to exchange. Both simulations and experiments showed dependence of kurtosis on number of cycles in OGSE waveforms for non-zero permeability.
conclusionThe results show significant time/frequency-dependency of diffusional kurtosis in the mouse brain, which can provide sensitivity to probe intrinsic cellular heterogeneity and pathological alterations in gray and white matter.
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