Evidence map›Paper›PMID 32022294›Full record

ArticleBritish journal of clinical pharmacology2020

Influence of SLCO1B1 polymorphisms on lopinavir C

Gordana Dragović, Božana Dimitrijević, Jovana Kušić, Ivan Soldatović, Djordje Jevtović, Adeniyi Olagunju, Andrew Owen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Influence of SLCO1B1 polymorphisms on lopinavir CBritish journal of clinical pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Gordana DragovićDepartment of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0002-0438-0309
Božana DimitrijevićDepartment of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0002-7978-2548
Jovana KušićDepartment of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-4918-9476
Ivan SoldatovićInstitute for Biomedical Statistics, School of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-4893-1683
Djordje JevtovićInfectious and Tropical Diseases Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-1127-6072
Adeniyi OlagunjuFaculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.ORCID 0000-0002-6588-5749
Andrew OwenDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.ORCID 0000-0002-9819-7651
University of Belgrade · RSObafemi Awolowo University · NGUniversity of Liverpool · GB

Funding

IATOS projectMinistry of Science and Technological Development of Serbia 175024
6 · The paper itself

Abstract

aimsLopinavir (LPV) is not a first-line regimen. According to recent WHO data, LPV usage in low- and middle-income countries accounted for approximately 52% of the adult and 23% of the paediatric protease inhibitor market in 2017. Since LPV is a substrate for the SLCO1B1 (OATP1B1) transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV trough plasma concentrations (C

methodsPlasma samples from 104 HIV/AIDS Caucasians were collected. LPV C

resultsThe overall mean (SD) LPV C

conclusionsOur results demonstrate a statistically significant influence of the SLCO1B1 rs4149056 polymorphism on higher LPV C

Indexed as

HIV InfectionsHIV Protease InhibitorsAdultChildGenotypeHumansLiver-Specific Organic Anion Transporter 1LopinavirPolymorphism, GeneticRitonavirHIV Protease InhibitorsLiver-Specific Organic Anion Transporter 1LopinavirRitonavirSLCO1B1 protein, humanHIV/AIDSlopinavirpharmacokineticsingle nucleotide polymorphismSLCO1B1

Identifiers

PMID32022294
PMCPMC7319006
OpenAlexW3004876156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.