Evidence map›Paper›PMID 32022101›Full record

ArticleActa cirurgica brasileira2020

New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.

Clóvis Ney Pinheiro Macêdo, Francisco Evanilso Silva Braga, Ana Paula Bomfim Soares Campelo, Gabriel Maia Diniz, Luiz Gonzaga de França Lopes, Marcos Kubrusly, Marcio Wilker Soares Campelo

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Clóvis Ney Pinheiro MacêdoFellow Master degree, Postgraduate Program in Minimally Invasive Technology and Health Simulation Area, Medical School, Centro Universitário Christus (UNICHRISTUS), Fortaleza-CE, Brazil. Conception and design of the study, technical procedures, acquisition and interpretation of data, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-6183-4629
Francisco Evanilso Silva BragaGraduate student, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Technical procedures, acquisition of data, manuscript preparation.ORCID http://orcid.org/0000-0002-3176-4033
Ana Paula Bomfim Soares CampeloPhD, Department of Surgery, Universidade Federal do Ceará (UFC), Fortaleza-CE, Brazil. Statistical analysis, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0001-9653-0409
Gabriel Maia DinizGraduate student, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Technical procedures, acquisition of data, manuscript preparation.ORCID http://orcid.org/0000-0002-8137-2417
Luiz Gonzaga de França LopesPhD, Full Professor, Chemistry Department, UFC, Fortaleza-CE, Brazil. Conception and design of the study, ruthenium synthese, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-3641-1835
Marcos KubruslyPhD, Full Professor, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Conception and design of the study, acquisition and interpretation of data, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-4414-8109
Marcio Wilker Soares CampeloPhD, Full Professor, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Conception and design of the study, acquisition and interpretation of data, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-2598-9586
Unichristus · BRUniversidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).

methodsWistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals.

resultsAt the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05).

conclusionRut-bpy may prevent renal histological changes in rats caused by meloxicam.

Indexed as

2,2'-DipyridylAnimalsAnti-Inflammatory Agents, Non-SteroidalFractalsKidney DiseasesMaleMeloxicamNitric Oxide DonorsOrganometallic CompoundsRandom AllocationRats, WistarReproducibility of ResultsRuthenium2,2'-DipyridylAnti-Inflammatory Agents, Non-SteroidalMeloxicamNitric Oxide DonorsOrganometallic CompoundsRuthenium

Identifiers

PMID32022101
PMCPMC6998060
OpenAlexW3005099194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.