ReviewAnnals of gastroenterological surgery2020
Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta-analysis.
Review in Annals of gastroenterological surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 57 citations in OpenAlex.
- Combination of albumin-lymphocyte score and skeletal muscle index predicts prognosis of patients with ovarian cancer after primary debulking surgery.Frontiers in immunology · 2026Article
- Efficacy and safety analysis of immune checkpoint inhibitor rechallenge in advanced esophageal squamous cell carcinoma: A retrospective study.Human vaccines & immunotherapeutics · 2025Article
- The predictive value of preoperative inflammatory status for anastomotic leakage after esophagectomy for esophageal cancer.Frontiers in oncology · 2025Article
- Pretreatment CALLY index as promising novel biomarker in the prediction of surgical and oncological outcomes in esophageal cancer: a multi-center retrospective cohort study.Frontiers in immunology · 2025Article
- A prognostic nomogram for T3N0M0 esophageal squamous cell carcinoma patients undergoing radical surgery based on computed tomography radiomics and inflammatory nutritional biomarkers.Journal of applied clinical medical physics · 2024Article
- The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective.Clinics and practice · 2024Article
- The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study.Cancer medicine · 2024Article
- Nomogram based on pretreatment hepatic and renal function indicators for survival prediction of locally advanced esophageal squamous cell carcinoma with treatment of neoadjuvant chemoradiotherapy plus surgery.Updates in surgery · 2024Article
- Identifying intense inflammatory subtype of esophageal squamous cell carcinoma using clustering approach.General thoracic and cardiovascular surgery · 2024Article
- The relationship between tumor-infiltrating neutrophils and clinical outcomes in patients with resectable hepatocellular carcinoma.BMC cancer · 2024Article
- Clinical Significance of the Preoperative Inflammatory Burden Index in Esophageal Cancer.Oncology · 2024Article
- Characterization of blood inflammatory markers in patients with non-small cell lung cancer.International journal of clinical and experimental pathology · 2024Article
- Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma.BMC cancer · 2023Article
- Prognostic value ofEsophagus : official journal of the Japan Esophageal Society · 2023Article
- Machine learning‑based prediction of survival prognosis in esophageal squamous cell carcinoma.Scientific reports · 2023Article
- A possible combined appraisal pattern: predicting the prognosis of patients after esophagectomy.World journal of surgical oncology · 2023Article
- Combination of neutrophil-to-lymphocyte ratio and albumin concentration to predict the prognosis of esophageal squamous cell cancer patients undergoing esophagectomy.Journal of thoracic disease · 2023Article
- The prognostic significance of preoperative nutritional/inflammatory markers and clinicopathological features in resectable esophagectomy patients: possibility of nutritional intervention.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Article
- Modified Glasgow prognostic score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: A propensity score-matched analysis.Thoracic cancer · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimImpact of several immune-inflammatory markers on long-term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta-analysis the oncological outcome of immune-inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C-reactive protein to albumin ratio (CAR) in esophageal cancer.
methodsA systematic electronic search for relevant studies was carried out in PubMed, Cochrane library, Embase, and Google scholar. Meta-analysis was done using hazard ratio (HR) and 95% confidence interval (CI) as effect measures. A systematic review and meta-analysis were undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.
resultsA total of 10 retrospective articles (n = 4551) were included in this study. Synthesized results showed that higher NLR and CAR were significantly associated with poor overall survival (HR 1.47, 95% CI = 1.32-1.63,
conclusionNLR and CAR represent useful guides for the management of esophageal cancer, although publication bias should be considered. Further prospective studies are needed to confirm the results of the present study.
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