Evidence map›Paper›PMID 32021912›Full record

ArticleClinical and translational radiation oncology2020

Multiple sclerosis as differential diagnosis of radionecrosis for post-irradiation brain lesions: A case report.

Florent Guillemin, Julian Biau, Sakahlé Conde, Pierre Clavelou, Guillaume Dupic

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical and translational radiation oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Florent GuilleminDepartment of Radiation Oncology, Jean Perrin Center, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Julian BiauDepartment of Radiation Oncology, Jean Perrin Center, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Sakahlé CondeDepartment of Neurology, University Hospital of Clermont-Ferrand, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Pierre ClavelouDepartment of Neurology, University Hospital of Clermont-Ferrand, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Guillaume DupicDepartment of Radiation Oncology, Jean Perrin Center, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Centre Jean Perrin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDemyelination can occur after brain radiotherapy in tissue adjacent to irradiated tumours. To date, no correlation has been found between conventional-dose radiotherapy and the development of multiple sclerosis, but radiotherapy could be a triggering factor among women with known multiple sclerosis. To the best of our knowledge, this is the first well-documented case of this association with a dosimetric analysis. CASE PRESENTATION: The case we report here describes the development of multiple sclerosis in a 36-year-old woman without significant past medical history 3 months after the last session of fractionated stereotactic radiotherapy for a pituitary macroadenoma. Our dosimetric analysis suggests that all the multiple sclerosis lesions occurred in the brain regions irradiated with a mean biologically effective dose (BED

conclusionConsequently special caution towards radiotherapy is required among patients with demyelinating illnesses or for 35-45-year-old women who are at risk. In addition, multiple sclerosis lesions can look like metastases. We should therefore keep differential diagnoses in mind in order not to make mistakes that would delay treatment.

Indexed as

BED, biologically effective doseCSF, cerebrospinal fluidCT, computed tomographyCTV, clinical target volumeDifferential diagnosisDosimetric analysisGTV, gross tumor volumeGy, grayIMRT, intensity modulated radiotherapyLS, Lhermitte’s syndromeMRI, magnetic resonance imageryMultiple sclerosisPTV, planning target volumeRadiotherapyVMAT, volumetric modulated arctherapy

Identifiers

PMID32021912
PMCPMC6993054
OpenAlexW2999916370

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.