ArticleToxicology reports2020
A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats.
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Life-Cycle Risk Assessment of Second-Generation Cellulose Nanomaterials.Nanomaterials (Basel, Switzerland) · 2025Article
- Evaluation of the cyto- and genotoxicity of two types of cellulose nanomaterials using human intestinal cells and in vitro digestion simulation.Archives of toxicology · 2025Article
- Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment-Part 2: Immunological Endpoints, Influence on the Intestinal Barrier and Microbiome.Nanomaterials (Basel, Switzerland) · 2024Article
- Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment-Part 1: The Systemic Effects.Nanomaterials (Basel, Switzerland) · 2024Article
- Article
- Toxicological evaluation of a pumpkin-derived pectin preparation: in vitro genotoxicity studies and a 13-week oral toxicity study in Sprague-Dawley rats.Toxicology research · 2024Article
- Ex vivo models for intestinal translocation studies of cellulose nanocrystals.In vitro models · 2023Article
- Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers.Polymers · 2023Review
- Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure.Nanomaterials (Basel, Switzerland) · 2022Review
- Bacterial Cellulose and Its Applications.Polymers · 2022Review
- Screening and prioritization of nano- and microplastic particle toxicity studies for evaluating human health risks - development and application of a toxicity study assessment tool.Microplastics and nanoplastics · 2022Article
- Nanocelluloses - Nanotoxicology, Safety Aspects and 3D Bioprinting.Advances in experimental medicine and biology · 2022Review
- Fluorescently Labeled Cellulose Nanofibers for Environmental Health and Safety Studies.Nanomaterials (Basel, Switzerland) · 2021Article
- A 90-Day Oral Toxicity Study of an Ethanolic Root Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Physical, chemical, and toxicological characterization of sulfated cellulose nanocrystals for food-related applications usingToxicology research · 2020Article
- Application of Nanotechnology in Wood-Based Products Industry: A Review.Nanoscale research letters · 2020Review
- Physical, chemical, and toxicological characterization of fibrillated forms of cellulose using anToxicology research · 2020Article
- Safety evaluation of a novel variant of consensus bacterial phytase.Toxicology reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel forms of fibrillated cellulose offer improved attributes for use in foods. Conventional cellulose and many of its derivatives are already widely used as food additives and are authorized as safe for use in foods in many countries. However, novel forms have not yet been thoroughly investigated using standardized testing methods. This study assesses the 90-day dietary toxicity of fibrillated cellulose, as compared to a conventional cellulose, Solka Floc. Sprague Dawley rats were fed 2 %, 3 %, or 4 % fibrillated cellulose for 90 consecutive days, and parallel Solka Floc groups were used as controls. Survival, clinical observations, body weight, food consumption, ophthalmologic evaluations, hematology, serum chemistry, urinalysis, post-mortem anatomic pathology, and histopathology were monitored and performed. No adverse observations were noted in relation to the administration of fibrillated cellulose. Under the conditions of this study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) for fibrillated cellulose was 2194.2 mg/kg/day (males) and 2666.6 mg/kg/day (females), corresponding to the highest dose tested (4 %) for male and female Sprague Dawley rats. These results demonstrate that fibrillated cellulose behaves similarly to conventional cellulose and raises no safety concerns when used as a food ingredient at these concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.