Evidence map›Paper›PMID 32021661›Full record

ArticleThe World Allergy Organization journal2020

Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study.

Misbah Noshela Ghazanfar, Line Kibsgaard, Simon Francis Thomsen, Christian Vestergaard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  10. Dupilumab as Add-on Therapy for Management of Chronic Spontaneous Urticaria.The Journal of clinical and aesthetic dermatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Misbah Noshela GhazanfarDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Line KibsgaardDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Simon Francis ThomsenDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Christian VestergaardDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Aarhus University Hospital · DKBispebjerg Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe autoimmune profile of Chronic Urticaria (CU) patients is an increasing topic of interest. Associated diseases suggest shared pathogenic pathways, and they may provide important knowledge on specific targets for future treatment models. In this study we examined the prevalence and risk of comorbidities in CU.

methodsThe Danish National Patient Registry was used to identify all CU patients from 1994 to 2015. Five of 5 specialized dermatological units in Denmark were covered. Analyses were conducted as a nested case control study and a matched cohort study. CSU patients were matched 1:10 on age and sex to an otherwise random group of people from the background population.

resultsA total of 12,185 CU patients were identified, with an overweight of female cases (69% versus 32%). There was an overrepresentation of mast cell mediated diseases including mastocytosis and anaphylaxis, as well as atopic diseases including type 1 allergies and atopic dermatitis. The prevalence of rheumatoid arthritis, systemic lupus erythematosus, thyroiditis and vitiligo was also increased, as was the prevalence of depression. CU patients who did not have any of the co-morbidities at the time of their CU diagnosis had an increased risk of developing both mast cell mediated diseases, atopic diseases, and autoimmune diseases excluding thyroiditis and diabetes.

conclusionThe autoimmune profile of the comorbidities of CU was demonstrated with an evident risk of developing rheumatoid arthritis. CU patients were also at increased risk of either having or achieving depression. Mast cell related diseases seemed to be overrepresented, although registry data within this disease category are questionable and similar to symptoms of CU to the untrained eye. Thus, CU patients constitute a multimorbid group of patients, which must be recognized among treating physicians.

Indexed as

AD, Atopic DermatitisANA, Anti Nuclear AntibodiesChronic urticariaComorbiditiesCSU, Chronic spontaneous urticariaCU, Chronic urticariaDCRR, Dnish Civil Registration RegistryDemographicsDNPR, Danish National Patient RegistryHR, Hazard RatioICD, International Classification of DiseasesIg, ImmunglobulinIncident riskOR, Odds rationPrevalenceRECORD, Reporting of Studies Conducted using observational Routinely Collected Health DataSLE, Systemic Lupus Erythematosus

Identifiers

PMID32021661
PMCPMC6994395
OpenAlexW3002698932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.