ArticleBiotechnology for biofuels2020
Fumarate production with
Article in Biotechnology for biofuels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Energy-translation coupling limits anaerobic yeast growth.Nature communications · 2026Article
- Utilizing drip metabolites and predictive modeling for non-destructive freshness assessment in pork loin.NPJ science of food · 2025Article
- Selective pertraction of dicarboxylic acids from simulated Rhizopus oryzae fermentation broths.Scientific reports · 2023Article
- Fungal-Lactobacteria Consortia and Enzymatic Catalysis for Polylactic Acid Production.Journal of fungi (Basel, Switzerland) · 2023Article
- Fractionation of dicarboxylic acids produced by Rhizopus oryzae using reactive extraction.Scientific reports · 2022Article
- Direct Extraction of Fumaric Acid fromBiomolecules · 2021Article
- Enhancement of Monascus yellow pigments production by activating the cAMP signalling pathway in Monascus purpureus HJ11.Microbial cell factories · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe four-carbon dicarboxylic acids of the tricarboxylic acid cycle (malate, fumarate and succinate) remain promising bio-based alternatives to various precursor chemicals derived from fossil-based feed stocks. The double carbon bond in fumarate, in addition to the two terminal carboxylic groups, opens up an array of downstream reaction possibilities, where replacement options for petrochemical derived maleic anhydride are worth mentioning. To date the most promising organism for producing fumarate is
resultsAll fermentations were performed with either nitrogen excess (growth phase) or nitrogen limitation (production phase) where medium replacements were done between the growth and the production phase. Initial experiments employed excess glucose for both growth and production, while the oxygen partial pressure was varied between a dissolved oxygen of 18.4% and 85%. Ethanol was formed during both growth and production phases and the oxygen partial pressure had zero influence on the response. Results clearly indicated that possible anaerobic zones within the mycelium were not responsible for ethanol formation, hinting that ethanol is formed under fully aerobic conditions as a metabolic overflow product. For Crabtree-positive organisms like
conclusionsThe results conclusively prove that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.