ReviewIranian journal of child neurology2020
Bilirubin Induced Encephalopathy.
Review in Iranian journal of child neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Importance of Bilirubin Molecular Species in Patients With Liver Cirrhosis Who Develop Hepatic Encephalopathy and Patients With Acute-on-chronic Liver Failure
Use of Serum Bilirubin/Albumin Ratio for Early Prediction of Bilirubin Induced Neurological Dysfunction
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.PloS one · 2021Pooled it
- Computer-aided diagnosis of neonatal acute bilirubin encephalopathy with multi-modal MRI images and convolutional neural networks.Scientific reports · 2026Article
- Article
- Hyperbilirubinemia and neurologic signs in dogs with non-associative immune-mediated hemolytic anemia: 81 cases (2015-2024).Journal of veterinary internal medicine · 2026Article
- Docosahexaenoic acid attenuates neuropathological alterations in a rodent model of neonatal bilirubin-induced encephalopathy.Frontiers in medicine · 2026Article
- Genetic insights into unexplained infant jaundice: a study from northern Guangdong, China.Frontiers in pediatrics · 2026Article
- Diagnosing acute bilirubin encephalopathy in neonates using MRI-based deep learning model.BMC pediatrics · 2025Article
- Transcriptomic and Proteomic Changes in the Brain Along with Increasing Phenotypic Severity in a Rat Model of Neonatal Hyperbilirubinemia.International journal of molecular sciences · 2025Article
- Detecting acute bilirubin encephalopathy in neonates based on multimodal MRI images and non-image clinical data.BMC pediatrics · 2025Article
- Effect of moderate hyperbilirubinemia on an infant's brain: a quantitative susceptibility mapping andFrontiers in pediatrics · 2025Article
- Determinants of jaundice severity in neonates admitted at a Teaching Hospital in Ghana.PloS one · 2025Article
- Causal association between pregnancy disorders and neonatal jaundice: a two-sample Mendelian randomization study.Translational pediatrics · 2024Article
- Dysregulated Glucuronidation of Bilirubin Exacerbates Liver Inflammation and Fibrosis in Schistosomiasis Japonica through the NF-κB Signaling Pathway.Pathogens (Basel, Switzerland) · 2024Article
- Magnetic resonance spectroscopy and auditory brain-stem response audiometry as predictors of bilirubin-induced neurologic dysfunction in full-term jaundiced neonates.European journal of pediatrics · 2024Article
- Developmental outcome of neonates underwent exchange transfusion due to hyperbilirubinemia: A single-center experience.Journal of education and health promotion · 2024Article
- A Novel Smartphone App for Self-Monitoring of Neonatal Jaundice Among Postpartum Mothers: Qualitative Research Study.JMIR mHealth and uHealth · 2023Article
- The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia.BMC medical imaging · 2023Article
- The added value of brain MR spectroscopy in children with Crigler-Najjar syndrome type-I: correlation with demographic, neurodevelopmental, and laboratory findings.The British journal of radiology · 2023Article
- Article
- Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperbilirubinemia is one of the most common neonatal disorders. Delayed diagnosis and treatment of the pathologic and progressive indirect hyperbilirubinemia lead to neurological deficits, defined as bilirubin induced encephalopathy (BIE) (2). The incidence of this disorder in underdeveloped countries is much more than developed areas. All neonates with the risk factors for increased the blood level of indirect bilirubin are at risk for BIE, especially preterm neonates which are prone to low bilirubin kernicterus . BIE can be transient and acute (with early, intermediate and advanced phases)or be permanent, chronic and lifelong ( with tetrad of symptoms including visual (upward gaze palsy), auditory (sensory neural hearing loss), dental dysplasia abnormalities, and extrapyramidal disturbances (choreoathetosis cerebral palsy).Beside the abnormal neurologic manifestations of the jaundiced neonates ,brain MRI is the best imaging modality for the confirmation of the diagnosis. Although early treatment of extreme hyperbilirubinemia by phototherapy and exchange transfusion can prevent the BIE, unfortunately the chronic bilirubin encephalopathy does not have definitive treatment.
Indexed as
Identifiers
32021624PMC6956966W3013465505What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.