ArticleOpen access emergency medicine : OAEM2020
Serum Cleaved Tau Protein and Clinical Outcome in Patients with Minor Head Trauma.
Article in Open access emergency medicine : OAEM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Blood biomarkers of secondary outcomes following concussion: A systematic review.Frontiers in neurology · 2023Pooled it
- Biomarkers of traumatic brain injury: narrative review and future prospects in neurointensive care.Frontiers in medicine · 2025Review
- mTBI Biological Biomarkers as Predictors of Postconcussion Syndrome-Review.Brain sciences · 2024Review
- Tau: a biomarker of Huntington's disease.Molecular psychiatry · 2023Review
- Comparing blood biomarkers to clinical decision rules to select patients suspected of traumatic brain injury for head computed tomography.The neuroradiology journal · 2023Article
- Tau as a fluid biomarker of concussion and neurodegeneration.Concussion (London, England) · 2022Review
- Examining four blood biomarkers for the detection of acute intracranial abnormalities following mild traumatic brain injury in older adults.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMinor head trauma is due to the transfer of a mechanical energy to the brain caused by a traumatic event. The present study was accomplished aiming to investigate the cleaved tau protein (CTP) as a brain injury biomarker among patients with minor head trauma. PATIENTS AND
methodsThis observational study was performed on patients with minor head trauma in 2017 who referred to emergency department of Imam Khomeini Hospital and Golestan Hospital of Ahvaz, Iran. The patients over the age of 16 years old with minor head trauma, who had computed tomography (CT) scan at most 10 hrs after the incident, and consented to participate in the study, were enrolled. C-tau evaluation was performed by the enzyme-linked immunosorbent assay (ELISA) method with monoclonal antibodies detecting the C-tau marker. Investigation of the injury after 3 months of minor head trauma was conducted using a post-concussion syndrome questionnaire (RPCS).
resultsIn this study, 86 patients were evaluated. CTP was positive in 14% of the patients and the results revealed that there was a significant relationship between traumatic brain injury (TBI) and positive CTP (p < 0.0001). The CTP had a sensitivity and specificity of, respectively, 92% and 100% in detecting intracranial trauma. In addition, positive and negative predictive powers for this marker were 100% and 98%, respectively.
conclusionIn general, contrary to previous studies, the findings of this study suggest that evaluation of the CTP levels can be a strong biomarker with high sensitivity and specificity in detecting TBI.
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