ArticleCancer management and research2020
Desmoplastic Reaction and Tumor Budding in Cervical Squamous Cell Carcinoma are Prognostic Factors for Distant Metastasis: A Retrospective Study.
Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial).British journal of cancer · 2021Trial
- Cervical metastasis in breast cancer: A case report.Oncology letters · 2026Article
- Desmoplastic reaction at the invasive front of upper urinary tract urothelial carcinoma: prognostic impact and associations with tumour invasiveness and immune-inflammatory status.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- Stromal grading predicts pathologic complete response and prognosis in triple-negative breast cancer.Virchows Archiv : an international journal of pathology · 2023Article
- Desmoplasia in cervical cancer is associated with a more aggressive tumor phenotype.Scientific reports · 2023Article
- Cancer-Associated Fibroblasts Influence Survival in Pleural Mesothelioma: Digital Gene Expression Analysis and Supervised Machine Learning Model.International journal of molecular sciences · 2023Article
- Rapid and label-free detection of gastrointestinal stromal tumor via a combination of two-photon microscopy and imaging analysis.BMC cancer · 2023Article
- Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma.Medical molecular morphology · 2022Article
- Single-cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer.Cell proliferation · 2022Article
- Development and Validation of a Nomogram for Predicting Postoperative Distant Metastasis in Patients with Cervical Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Review
- A Novel Superpixel Approach to the Tumoral Microenvironment in Colorectal Cancer.Journal of pathology informatics · 2022Article
- Tumor budding of cervical squamous cell carcinoma: epithelial-mesenchymal transition-like cancer stem cells?PeerJ · 2022Article
- Development and Validation of a Novel Prognostic Nomogram Combined With Desmoplastic Reaction for Synchronous Colorectal Peritoneal Metastasis.Frontiers in oncology · 2022Article
- Predicting lymph node metastasis and recurrence in patients with early stage colorectal cancer.Frontiers in medicine · 2022Article
- Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment.Scientific reports · 2021Article
- Histopathological atlas of desmoplastic reaction characterization in colorectal cancer.Japanese journal of clinical oncology · 2021Article
- Understanding the role of indoleamine-2,3-dioxygenase and stromal differentiation in rare subtype endometrial cancer.Rare tumors · 2021Article
- Nature and significance of stromal differentiation in carcinosarcoma (MMMT): unravelling the biology and shifting current paradigms.Rare tumors · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn accurate risk assessment system for disease metastasis or recurrence could improve the cancer management practice in cervical squamous cell carcinoma (CxSCC) patients, which has few definite prognostic predictors. Previous studies have indicated the important utility of stromal features in determining cancer biological behavior; however, it lacks histopathologic or morphologic criteria for its evaluation. Therefore, this present study aimed to comprehensively catalog histopathological features of mesenchymal stroma to determine the prognostic value of these features in CxSCC. PATIENTS AND
methodsWe histologically and immunohistochemically evaluated the stromal features in the primary tumors of 122 CxSCC patients. The follow-up duration was 41.25 months (range: 3-80.77 months). Multivariate proportional hazard regression models were used to identify the top classifier for distant metastasis-free survival (DMFS) prediction.
resultsLymph-vascular invasion (LVI), lymph node metastasis (LNM), tumor-node-metastasis (TNM) stage and tumor budding were positively correlated with distant metastasis (
conclusionPrimary tumor histologic stromal features, especially DR, may be useful in predicting distant metastasis in patients with CxSCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.