Evidence map›Paper›PMID 32021379›Full record

ReviewThe application of clinical genetics2020

The Importance of Small Non-Coding RNAs in Human Reproduction: A Review Article.

Behnam Kamalidehghan, Mohsen Habibi, Sara S Afjeh, Maryam Shoai, Saeideh Alidoost, Rouzbeh Almasi Ghale, Nahal Eshghifar, Farkhondeh Pouresmaeili

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The application of clinical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  5. Observational
  6. Article
  7. MicroRNAs as Biomarkers and Therapeutic Targets in Female Infertility.International journal of molecular sciences · 2024
    Review
  8. The Relationship between The Expression of SpermInternational journal of fertility & sterility · 2024
    Article
  9. Article
  10. Article
  11. Exosome miR-4738-3p-mediated regulation ofBiomolecules & biomedicine · 2024
    Article
  12. Review
  13. Review
  14. The effect of MicroRNAs variants on idiopathic recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2023
    Article
  15. Review
  16. Review
  17. Analysis of C. elegans Germline Small RNA Pathways.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Review
  19. Article
  20. The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Behnam Kamalidehghan *Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohsen Habibi *Central Laboratory, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sara S AfjehDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam ShoaiDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Saeideh AlidoostDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Rouzbeh Almasi GhaleDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nahal EshghifarDepartment of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran and Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farkhondeh PouresmaeiliDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IRUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroRNAs (miRNA) play a key role in the regulation of gene expression through the translational suppression and control of post-transcriptional modifications.

aimPrevious studies demonstrated that miRNAs conduct the pathways involved in human reproduction including maintenance of primordial germ cells (PGCs), spermatogenesis, oocyte maturation, folliculogenesis and corpus luteum function. The association of miRNA expression with infertility, polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and repeated implantation failure (RIF) was previously revealed. Furthermore, there are evidences of the importance of miRNAs in embryonic development and implantation. Piwi-interacting RNAs (piRNAs) and miRNAs play an important role in the post-transcriptional regulatory processes of germ cells. Indeed, the investigation of small RNAs including miRNAs and piRNAs increase our understanding of the mechanisms involved in fertility. In this review, the current knowledge of microRNAs in embryogenesis and fertility is discussed.

conclusionFurther research is necessary to provide new insights into the application of small RNAs in the diagnosis and therapeutic approaches to infertility.

Indexed as

female fertilitymale fertilitymiRNApiRNAspiwi-interacting RNAs

Identifiers

PMID32021379
PMCPMC6956659
OpenAlexW2999039231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.