ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2020
Systemic Inflammation Mediates the Associations Between Abdominal Obesity Indices and Lung Function Decline in a Chinese General Population.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A systematic review and meta-analysis of obesity and COVID-19 outcomes.Scientific reports · 2021Pooled it
- Association between body roundness index and lung function among U.S. adults.BMC public health · 2025Article
- The Relationship Between Anthropometric Variables and Lung Function in a Severe Smoking Community Population With Ventilatory Dysfunction.The clinical respiratory journal · 2025Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Association between waist circumference and lung function in American middle-aged and older adults: findings from NHANES 2007-2012.Journal of health, population, and nutrition · 2024Article
- Associations of short-term ambient temperature exposure with lung function in middle-aged and elderly people: A longitudinal study in China.Eco-Environment & Health · 2024Article
- Review
- Body Composition and COPD: A New Perspective.International journal of chronic obstructive pulmonary disease · 2023Review
- Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study.Nutrients · 2021Article
- The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research.International journal of environmental research and public health · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies reported that obesity indices were inversely associated with lung function. However, the underlying mechanisms remain unclear. We aimed to assess the potential mediating effect of systemic inflammation in the associations between obesity indices and lung function decline among a general population.
methodsWe conducted a cross-sectional study among 3442 participants from the Wuhan-Zhuhai cohort. Plasma C-reactive protein (CRP) was assayed as a marker of systemic inflammation. The relationships among several obesity indices (body mass index, BMI; waist circumference, WC; waist-to-hip ratio, WHR; waist-to-height ratio, WHtR), plasma CRP and lung function were assessed by generalized linear models. The role of CRP in the associations between obesity indices and lung function was analyzed using mediation analysis.
resultsWe observed inverse associations between abdominal obesity indices (WC, WHR and WHtR) and lung function parameters, including forced expiratory volume in 1 s (FEV
conclusionAbdominal obesity indices were negatively associated with lung function, and the associations may be partly mediated by systemic inflammation.
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Registered trials
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