ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2019
The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Antioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials.Inflammopharmacology · 2025Pooled it
- Efficacy of nonsurgical periodontal treatment on patients with periodontitis and type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis.Acta odontologica Scandinavica · 2025Pooled it
- Article
- Ginger as a Potential Remedy for Periodontitis Treatment: A Review on the Present Evidence.Health science reports · 2025Article
- Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East.Sultan Qaboos University medical journal · 2025Review
- "The effects of non-surgical periodontal treatment plus zinc and magnesium supplementation on oxidative stress and antioxidants enzymes in type 2 diabetes patients: a quasi-experimental study".BMC oral health · 2024Article
- Therapeutic Potential of Ginger Exosome-Like Nanoparticles for Alleviating Periodontitis-Induced Tissue Damage.International journal of nanomedicine · 2024Article
- Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications.Metabolites · 2022Review
- Effect of date palm pollen supplementation on female sexual function in non-menopausal women: A double blind randomized clinical trial.Chinese herbal medicines · 2022Article
- Host Response Modulation Therapy in the Diabetes Mellitus-Periodontitis Conjuncture: A Narrative Review.Pharmaceutics · 2022Review
- Postoperative Analgesic and Anti-inflammatory Effectiveness of Ginger (Zingiber officinale) and NSAIDs as Adjuncts to Nonsurgical Periodontal Therapy for the Management of Periodontitis.Oral health & preventive dentistry · 2022Article
- Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis.Journal of clinical medicine · 2022Review
- The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.Inflammopharmacology · 2022Review
- Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis.Experimental and therapeutic medicine · 2021Article
- Associations between new and old anthropometric indices with type 2 diabetes mellitus and risk of metabolic complications: a cross-sectional analytical study.Jornal vascular brasileiro · 2021Article
- Ginger from Farmyard to Town: Nutritional and Pharmacological Applications.Frontiers in pharmacology · 2021Review
- The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP) under non-surgical periodontal therapy (NSPT). MATERIAL AND
methodsIn this double-blind clinical trial study, 46 T2DM patients with CP were randomly allocated to intervention and control groups and received either 4 tablets 500 mg (2 g) ginger or placebo twice a day for 8 weeks. All patients were treated with NSPT during the intervention period. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), periodontal indices including clinical attachment loss (CAL), bleeding on probing (BOP), pocket depth (PD), and plaque index were evaluated in all subjects pre- and post-intervention.
resultsFollowing 8 weeks of ginger treatment with NSPT, significant reductions were observed in the mean levels of IL-6 (
conclusionIt is recommended that ginger supplementation along with NSPT may be effective in the improvement of inflammation, oxidative, and periodontal status in T2DM with CP.
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