ArticleNeuropsychiatric disease and treatment2020
Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study.
Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Association of platelet-to-lymphocyte ratio with depression risk: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Fremanezumab for the Treatment of Patients With Migraine and Comorbid Major Depressive Disorder: The UNITE Randomized Clinical Trial.JAMA neurology · 2025Trial
- The Hidden Burden of Depression in STEMI: Effects on Early Complications and 12-Month MACCE.Diagnostics (Basel, Switzerland) · 2026Article
- Combined impact of inflammation score and depression on clinical outcomes in patients after percutaneous coronary intervention: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
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- The systemic immune-inflammation index (SII) as a biomarker for depression in a community sample of adolescents.Comprehensive psychoneuroendocrinology · 2025Article
- Association Between Periodontal Pathogens and Inflammation in Patients with Acute Coronary Syndromes.International journal of molecular sciences · 2025Article
- Analysis of epidemiological characteristics and psychopsychological factors of arrhythmia in the elderly.World journal of psychiatry · 2025Article
- TLR4 identified as a major depressive disorder gene signature mediating effects through multiple immune cells.Scientific reports · 2025Article
- Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005-2018.BMC psychiatry · 2025Article
- Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson's disease.Frontiers in psychiatry · 2025Article
- Association between systemic immune-inflammation index at admission and post-stroke depression in patients with acute ischemic stroke.Frontiers in neurology · 2025Article
- Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder.BMC psychiatry · 2024Article
- Inflammatory mediators in major depression and bipolar disorder.Translational psychiatry · 2024Review
- Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA.Life (Basel, Switzerland) · 2024Article
- Methamphetamine Use Disorder and Inflammation: A Case-Control Study.Psychiatry investigation · 2024Article
- The interplay between Sars-Cov-2 infection related cardiovascular diseases and depression. Common mechanisms, shared symptoms.American heart journal plus : cardiology research and practice · 2024Review
- Development and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe risk of coronary heart disease (CHD) in patients with major depressive disorder (MDD) is higher than that in the general population. However, the mechanisms underlying the increased CHD risk in patients with MDD remain unclear. Inflammation plays an important role in the pathogenesis of MDD and CHD. Therefore, we explored the relationship between inflammatory biomarkers and CHD risk in patients with MDD.
methodsWe included 454 patients with acute MDD and 458 controls that matched the sample in age and gender. A readily available complete blood count was used to reflect inflammation, and the risk of CHD was assessed using the Framingham risk score.
resultsThe results showed that patients with MDD showed low-grade inflammation with an elevated platelet (p<0.001) and monocyte count (p<0.001), high platelet/lymphocyte (p=0.003) and monocyte/lymphocyte ratios (p<0.001), and a raised systemic immune-inflammation index (p=0.002). In addition, monocyte count was the only factor significantly associated with CHD risk in patients with MDD (B=7.521, 95% CI: 3.409-11.633, t=3.594, p<0.001).
conclusionCollectively, the results of this study support the hypothesis that MDD is systemic inflammation, and suggest that monocyte count predicts the risk of CHD in patients with MDD.
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