Evidence map›Paper›PMID 32021185›Full record

ReviewInternational journal of nanomedicine2020

Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions.

Hossein Derakhshankhah, Samira Jafari, Sajad Sarvari, Ebrahim Barzegari, Faezeh Moakedi, Milad Ghorbani, Behrang Shiri Varnamkhasti, Mehdi Jaymand, Zhila Izadi, Lobat Tayebi

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Nanoparticles in Medicine: Current Status in Cancer Treatment.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hossein Derakhshankhah *Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID 0000-0002-0951-2729
Samira Jafari *Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID 0000-0003-4443-1411
Sajad SarvariDepartment of Pharmaceutical and Pharmacological Science, School of Medicine, West Virginia University, Morgantown, WV, USA.
Ebrahim BarzegariMedical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID 0000-0002-4412-6129
Faezeh MoakediDepartment of Biochemistry and Molecular Biology, School of Medicine, West Virginia University, Morgantown, WV, USA.ORCID 0000-0001-6250-7489
Milad GhorbaniDepartment of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Behrang Shiri VarnamkhastiPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mehdi JaymandNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID 0000-0003-1416-4543
Zhila IzadiPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID 0000-0002-4546-5202
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI 53201, USA.ORCID 0000-0003-1947-5658

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles' interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated.

Indexed as

Amyloid beta-PeptidesAnimalsContrast MediaDrug Delivery SystemsFibrinogenGastrointestinal DiseasesHumansHydrogelsMagnetic Resonance ImagingNanomedicineNanoparticlesOsteogenesisPorosityRenal DialysisZeolitesAmyloid beta-PeptidesContrast MediaFibrinogenHydrogelsZeolitesbiomedical applicationsbiosafetymesoporousnanostructurezeolite

Identifiers

PMID32021185
PMCPMC6983480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.