ArticleDrug design, development and therapy2019
Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway.
Article in Drug design, development and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of Sevoflurane on the Proliferation, Migration, and Xenograft Growth of HepG2 Hepatocellular Carcinoma Cells: An Exploratory In Vitro and In Vivo Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1.Combinatorial chemistry & high throughput screening · 2025Article
- Effects of anesthetics on development of gynecological cancer.Frontiers in cell and developmental biology · 2025Review
- The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway.Cell biology and toxicology · 2024Article
- Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis.Heliyon · 2024Article
- Endoplasmic reticulum stress response pathway-mediated cell death in ovarian cancer.Frontiers in oncology · 2024Review
- Effect of Sevoflurane on the Proliferation of A549 Lung Cancer Cells.Medicina (Kaunas, Lithuania) · 2023Article
- Does the Choice of Anaesthesia Affect Cancer? A Molecular Crosstalk between Theory and Practice.Cancers · 2022Review
- The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.Cancer medicine · 2022Article
- CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis.Cell biology and toxicology · 2022Article
- Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis.Metabolic brain disease · 2022Article
- Prognostic biomarker MCP-4 triggers epithelial-mesenchymal transitionFrontiers in oncology · 2022Article
- Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis.Metabolic brain disease · 2021Article
- Sevoflurane blocks glioma malignant development by upregulating circRELN through circRELN-mediated miR-1290/RORA axis.BMC anesthesiology · 2021Article
- Sevoflurane inhibits malignant progression of colorectal cancer via hsa_circ_0000231-mediated miR-622.Journal of biological research (Thessalonike, Greece) · 2021Article
- Anesthetics or anesthetic techniques and cancer surgical outcomes: a possible link.Korean journal of anesthesiology · 2021Review
- Sevoflurane represses the migration and invasion of gastric cancer cells by regulating forkhead box protein 3.The Journal of international medical research · 2021Article
- Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors.Cancer management and research · 2020Review
- Anti-Tumor Xanthones fromDrug design, development and therapy · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSevoflurane is a halogen inhaled anesthetic, and we aimed to probe the effect of sevoflurane on proliferation and invasion of human ovarian cancer (OC) and its mechanism.
methodsOC cell lines were divided into 4 groups including control, sevoflurane low concentration (1.7%), medium concentration (3.4%) and high concentration (5.1%) groups. Flow cytometry and MTT assay were, respectively, employed to detect the cell apoptosis and proliferation. Transwell assay was applied to measure the cell migration and invasion viability. The gene and protein expressions were assessed using qRT-PCR and Western blot. The expressions of MAPK signaling pathway-related proteins were evaluated by Western blot. The p38 and JNK inhibitors were, respectively, added into the high concentration group to analyze the relationship between sevoflurane and modulatingmitogen-activated protein kinase (MAPK) pathway in OC. Nude mice models were constructed to explore the effect of sevoflurane on OC tumor growth in vivo.
resultsSevoflurane inhibited OC proliferation in vitro and in vivo. It could also promote OC cell apoptosis in a dose-dependent manner. Sevoflurane suppressed the OC cell migration and invasion, and these effects were positively correlated with the dose of sevoflurane. Moreover, sevoflurane treatment inhibited the expressions of PCNA, Twist, cleaved-caspase-3/caspase-3, MMP-2 and MMP-9. In addition, sevoflurane repressed the phosphorylation of JNK and p38 MAPK. When the MAPK pathway was interdicted, the cell proliferation, apoptosis, migration and invasion activity were recovered after sevoflurane treatment.
conclusionSevoflurane affected cell biological activities in OC by regulating JNK and p38 MAPK signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.