Trial reportBMC complementary medicine and therapies2020
Potential benefits of oral administration of AMORPHOPHALLUS KONJAC glycosylceramides on skin health - a randomized clinical study.
Trial report in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Prospective, Randomized, Double-Blind, Placebo-Controlled Study of an Oral Antioxidant-Rich Synbiotic Supplement on Skin Health and Photoaging.Journal of cosmetic dermatology · 2026Trial
- A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial for the Efficacy and Safety of a Novel Nutraceutical for Mild-to-Moderate Acne.Journal of cosmetic dermatology · 2025Trial
- Safety and Clinical Efficacy of KūlarisClinical, cosmetic and investigational dermatology · 2025Trial
- Trial
- Effect of Rice (Nutrients · 2022Trial
- Sphingolipid Metabolism in Obesity: Bidirectional Regulation and Comparative Perspectives on Plant Sphingolipids.Nutrients · 2026Review
- Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes.Biomolecules · 2026Article
- Influence of Oral Collagen Peptides on Skin Biophysical Properties in Humans: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.Dermatology and therapy · 2025Article
- The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis.Journal of advanced research · 2025Review
- Effect of Ceramides Derivatives from the Peach on Skin Function Improvement in UV-Irradiated Hairless Mice.Foods (Basel, Switzerland) · 2024Article
- Discovery ofJournal of fungi (Basel, Switzerland) · 2024Article
- Ceramides as Emerging Players in Cardiovascular Disease: Focus on Their Pathogenetic Effects and Regulation by Diet.Advances in nutrition (Bethesda, Md.) · 2024Review
- GenusPlants (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeramides play a fundamental role in maintaining the skin health as a function of improved barrier permeability. Reduced ceramide content results in skin dryness and wrinkledness. Intake of dietary ceramides potentially compensates the skin ceramide content. In the present study we have assessed the skin health benefits of oral supplementation of a hydroalcoholic extract from Amorphophallus konjac tubers standardized to 5% glycosylceramides, in a placebo-controlled clinical trial.
methodsFifty-one healthy human volunteers (aged 18-60 years) were supplemented with 100 mg/day of either a placebo or A. konjac extract capsules (5 mg glycosylceramides) for 6-weeks. The skin parameters were evaluated through dermatological diagnosis. Subject perceived efficacy of the product was further evaluated by a self-assessment questionnaire.
resultsOral intake of A. konjac extract significantly decreased the skin dryness, hyperpigmentation, redness, itching and oilyness (p < 0.05). The improvement in skin health following intake of A. konjac extract was observed to be time-dependent from the start. Further, A. konjac extract was well-tolerated throughout the study, as no adverse events or toxic changes were recorded.
conclusionThe study demonstrates the skincare properties of orally ingested glycosyl ceramides from konjac tubers.
trial registrationCTRI/2018/12/016661 dated 13/12/2018 retrospectively registered, http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=19851&EncHid=&userName=SkinCera.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.