ArticleJournal of cachexia, sarcopenia and muscle2020
High muscle-to-fat ratio is associated with lower risk of chronic kidney disease development.
Article in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Congener-Specific Associations of Per- and Polyfluoroalkyl Substances With Obesity-Metabolic Phenotypes: A Multimodel Analysis.Obesity (Silver Spring, Md.) · 2026Article
- Body Muscle-to-Fat Ratio (BMFR) as a Promising Anthropometric Index for Use in the Evaluation of Insulin Resistance and Metabolic Disease Risk: a Narrative Review.Current obesity reports · 2025Review
- Enhancing risk stratification in diabetic gastric cancer: muscle-fat ratio from photon-counting CT as a predictor of postoperative complications.BMC medical imaging · 2025Article
- Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments.Nutrition journal · 2025Article
- High muscle-to-fat ratio predicts slow muscle strength decline in middle-aged and older adults: Longitudinal aging study of Taipei.Journal of the Chinese Medical Association : JCMA · 2025Article
- Body Mass Index in Late Adolescence and Later Life Kidney Outcomes: A Population-Based Cohort Study in Swedish Men.Kidney medicine · 2025Article
- Prevalence of Chronic Kidney Disease and Its Association with Fat-to-Muscle Ratio in Ethnic Minority Areas of Southern China: A Cross-Sectional Study.International journal of general medicine · 2025Article
- Article
- Changes in muscle-to-fat ratio are associated with lung function decline and airflow obstruction in the general population.Respiratory research · 2024Article
- Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study.BMC cardiovascular disorders · 2024Article
- Association of serum calcium and metabolically healthy obese in US adults: a cross-sectional study.Annals of medicine · 2024Article
- Association between total body muscle-fat ratio and risk of thyroid disorders: a cross-sectional study.BMC public health · 2024Article
- Adiponectin-to-leptin ratio and incident chronic kidney disease: Sex and body composition-dependent association.Journal of cachexia, sarcopenia and muscle · 2024Article
- Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults.Frontiers of medicine · 2024Article
- Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ≈38 000 UK Biobank participants: a population-based observational study.Clinical kidney journal · 2024Article
- The inverse associations between composite-dietary-antioxidant-index and sarcopenia risk in US adults.Frontiers in endocrinology · 2024Article
- Total muscle-to-fat ratio influences urinary incontinence in United States adult women: a population-based study.Frontiers in endocrinology · 2024Article
- Prognostic value of total body muscle-fat ratio in patients with kidney stone disease: A US population-based study.Heliyon · 2023Article
- Association Between Visceral Fat Area and Glycated Hemoglobin in Type 2 Diabetics: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Gender similarities and differences in skeletal muscle and body composition: an MRI study of recreational cyclists.BMJ open sport & exercise medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity, a known risk factor for chronic kidney disease (CKD), is generally assessed using body mass index (BMI). However, BMI may not effectively reflect body composition, and the impact of muscle-to-fat (MF) mass balance on kidney function has not been elucidated. This study evaluated the association between body muscle and fat mass balance, represented as the MF ratio, and incident CKD development.
methodsData were retrieved from a prospective community-based cohort study (Korean Genome and Epidemiology Study). Muscle and fat mass were measured using multifrequency bioelectrical impedance analysis. The study endpoint was incident CKD (estimated glomerular filtration rate <60 mL/min/1.73 m
resultsTotally, 7682 participants were evaluated. Their mean age was 51.7 ± 8.7 years, and 48% of the subjects were men. During a median follow-up of 140.0 (70.0-143.0) months, 633 (8.2%) subjects developed incident CKD. When the association between body composition and incident CKD was investigated, multivariable Cox proportional hazard analysis revealed that increase in MF ratio was related with a decreased risk of CKD development [per 1 increase in MF ratio: hazard ratio (HR), 0.86; 95% confidence interval (CI), 0.77-0.96; P = 0.008]. This association was also maintained when MF ratio was dichotomized according to sex-specific median values (high vs. low: HR, 0.83; 95% CI, 0.70-0.98; P = 0.031). Analyses preformed in a propensity score matched group also revealed a similar decreased risk of incident CKD in high MF ratio participants (high vs. low: HR, 0.84; 95% CI, 0.71-0.98; P = 0.037). This relationship between MF ratio and incident CKD risk was consistently significant across subgroups stratified by age, sex, hypertension, estimated glomerular filtration rate categories, and proteinuria. Among different BMI groups (normal, overweight, and obese), the relationship between high MF ratio and lower incident CKD risk was significant only in overweight and obese subjects.
conclusionsLower fat mass relative to muscle mass may lower the risk of CKD development in individuals with normal renal function. This relationship seems more prominent in overweight and obese subjects than in normal weight subjects.
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