ArticleJournal of diabetes investigation2020
Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men.
Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- GLP-1, GIP, and Glucagon Excursions During a Mixed Meal Tolerance Test in Young and Lean South Asians Versus Europids.Diabetes, obesity & metabolism · 2026Trial
- Trial
- Diagnostic performance of 1-hour plasma glucose and glucose curve shape during oral glucose tolerance test: a cross-sectional study in a Brazilian cohort.Diabetology & metabolic syndrome · 2025Article
- Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2025Article
- Association of OGTT-curve Shape With Anthropometric, Metabolic, and Inflammatory Parameters in Healthy Adults.Journal of the Endocrine Society · 2025Article
- Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes.Diabetes care · 2025Article
- Characteristics and Risk of Diabetes in People With Rare Glucose Response Curve During an Oral Glucose Tolerance Test.The Journal of clinical endocrinology and metabolism · 2024Article
- Silymarin Reduced Insulin Resistance in Non-Diabetic Women with Obesity.International journal of molecular sciences · 2024Article
- The Glycemic Curve during the Oral Glucose Tolerance Test: Is It Only Indicative of Glycoregulation?Biomedicines · 2023Article
- Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound.International journal of environmental research and public health · 2022Article
- Oral glucose tolerance test in diabetes, the old method revisited.World journal of diabetes · 2021Review
- Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men.Journal of diabetes investigation · 2020Article
- Article
- The Oral Glucose Tolerance Test: 100 Years Later.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
Corrections and comments
- Erratum issuedCorrigendum.2021
Authors and funding
18 authors.
Funding
Abstract
Individuals with a monophasic glucose response curve (GRC) during a 75-g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non-obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue-specific insulin sensitivity and insulin clearance using a two-step hyperinsulinemic-euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non-obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.
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