ArticleJournal of the American Geriatrics Society2020
Aging, Diabetes, Obesity, and Cognitive Decline: A Population-Based Study.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Magnetic resonance spectroscopy study of cognitive impairment associated with cerebral small vessel disease.Brain imaging and behavior · 2026Article
- Magnetic resonance spectroscopy study of cognitive impairment associated with cerebral small vessel disease.Brain imaging and behavior · 2026Article
- Additive effects of depression and abdominal obesity on cognitive function in middle-aged and older population: evidence from multinational cohorts.BMC medicine · 2025Article
- Voxel-wise insights into early Alzheimer's disease pathology progression: the association with APOE and memory decline.GeroScience · 2025Article
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- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
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- Interrupted Learning across the Lifespan.Human development · 2025Article
- Calorie Restriction Attenuates Memory Impairment and Reduces Neuroinflammation in Obese Aged Rats.Molecular neurobiology · 2025Article
- Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences.GeroScience · 2025Article
- Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta.Molecular neurobiology · 2025Article
- Article
- Cognitive decline and diabetes in the clinical setting.Medicine and pharmacy reports · 2025Article
- The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies.Biomedicines · 2024Review
- Towards a Deeper Understanding: Utilizing Machine Learning to Investigate the Association between Obesity and Cognitive Decline-A Systematic Review.Journal of clinical medicine · 2024Review
- Optimal cardiovascular health is associated with slower cognitive decline.European journal of neurology · 2024Article
- Sex differences in the association between Body Mass Index and cognitive function in Parkinson disease: a cross-sectional study.Frontiers in nutrition · 2024Article
- Does education moderate gender disparities in later-life memory function? A cross-national comparison of harmonized cognitive assessment protocols in the United States and India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Bidirectional Associations Between Adiposity and Cognitive Function: A Prospective Analysis of the Canadian Longitudinal Study on Aging (CLSA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome.Cell & bioscience · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesTo investigate potential mechanisms underlying the well-established relationship of diabetes and obesity with cognitive decline, among older adults participating in a population-based study. DESIGN/
settingTen-year population-based cohort study.
participantsA total of 478 individuals aged 65 years and older. MEASUREMENTS: We assayed fasting blood for markers of glycemia (glucose and hemoglobin A1c [HbA1c]), insulin resistance (IR) (insulin and homeostatic model assessment of IR), obesity (resistin, adiponectin, and glucagon-like peptide-1), and inflammation (C-reactive protein). We modeled these indices as predictors of the slope of decline in global cognition, adjusting for age, sex, education, APOE*4 genotype, depressive symptoms, waist-hip ratio (WHR), and systolic blood pressure, in multivariable regression analyses of the entire sample and stratified by sex-specific median WHR. We then conducted WHR-stratified machine-learning (Classification and Regression Tree [CART]) analyses of the same variables.
resultsIn multivariable regression analyses, in the entire sample, HbA1c was significantly associated with cognitive decline. After stratifying by median WHR, HbA1c remained associated with cognitive decline in those with higher WHR. No metabolic indices were associated with cognitive decline in those with lower WHR. Cross-validated WHR-stratified CART analyses selected no predictors in participants older than 87 to 88 years. Faster cognitive decline was associated, in lower WHR participants younger than 87 years, with adiponectin of 11 or greater; and in higher WHR participants younger than 88 years, with HbA1c of 6.2% or greater.
conclusionsOur population-based data suggest that, in individuals younger than 88 years with central obesity, even modest degrees of hyperglycemia might independently predispose to faster cognitive decline. In contrast, among those younger than 87 years without central obesity, adiponectin may be a novel independent risk factor for cognitive decline. J Am Geriatr Soc 68:991-998, 2020.
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