Evidence map›Paper›PMID 32020584›Full record

ReviewImmunology2020

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Simon D Harding, Elena Faccenda, Christopher Southan, Adam J Pawson, Pasquale Maffia, Stephen P H Alexander, Anthony P Davenport, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding and 1 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. The IUPHAR/BPS Guide to PHARMACOLOGY in 2026.Nucleic acids research · 2026
    Article
  2. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.Nucleic acids research · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Simon D HardingDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9262-8318
Elena FaccendaDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
Christopher SouthanDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
Adam J PawsonDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
Pasquale MaffiaCentre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Stephen P H AlexanderSchool of Life Sciences, University of Nottingham Medical School, Nottingham, UK.
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.
Doriano FabbroCellestia Biotech SA, Basel, Switzerland.
Francesca Levi-SchafferInstitute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
Michael SpeddingSpedding Research Solutions SAS, Le Vésinet, France.
Jamie A DaviesDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
University of Edinburgh · GBCell Biotech (South Korea) · KRHebrew University of Jerusalem · ILInstitute of Infection and Immunity · CAUniversity of Cambridge · GBUniversity of Nottingham · GB

Funding

Wellcome Trust 108420/Z/15/Z
6 · The paper itself

Abstract

Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

Indexed as

Databases, PharmaceuticalDrug DevelopmentDrug DiscoveryAllergy and ImmunologyAntibodies, Monoclonal, HumanizedAtherosclerosisHumansImmune SystemImmunologic FactorsInflammation MediatorsInternational CooperationMolecular Targeted TherapyPharmaceutical ResearchPharmacology, ClinicalRandomized Controlled Trials as TopicSignal TransductionAntibodies, Monoclonal, HumanizedcanakinumabImmunologic FactorsInflammation Mediatorsdatabaseimmune-therapeuticsimmunopharmacologypharmacology

Identifiers

PMID32020584
PMCPMC7160657
OpenAlexW3004758109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.