Evidence map›Paper›PMID 32020478›Full record

ArticleJournal of neuro-oncology2020

Objective assessment of intraoperative tumor fluorescence reveals biological heterogeneity within glioblastomas: a biometric study.

Aliasgar Moiyadi, Prakash Shetty, Epari Sridhar, Vikram Gota, Murari Gurjar, Ghantasala Saicharan, Vikas Singh, Sanjeeva Srivastava

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In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aliasgar MoiyadiDivision of Neurosurgery, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National University, 1221, Homi Bhabha Block, Mumbai, India. aliasgar.moiyadi@gmail.com.ORCID http://orcid.org/0000-0002-4082-2004
Prakash ShettyDivision of Neurosurgery, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National University, 1221, Homi Bhabha Block, Mumbai, India.
Epari SridharDepartment of Surgical Pathology, Tata Memorial Centre, Homi Bhabha National University, Mumbai, India.
Vikram GotaDepartment of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Homi Bhabha National University, Mumbai, India.
Murari GurjarDepartment of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Homi Bhabha National University, Mumbai, India.
Ghantasala SaicharanDepartment of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
Vikas SinghDivision of Neurosurgery, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National University, 1221, Homi Bhabha Block, Mumbai, India.
Sanjeeva SrivastavaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
Homi Bhabha National Institute · INIndian Institute of Technology Bombay · IN

Funding

RENAL PATHOGENICITY OF ANTIDNA ANTIBODIESK08AR002015 · NIAMS · YESHIVA UNIVERSITY · PI PUTTERMAN, CHAIM · 1997 to 2001
$252k
Department of Biotechnology, Government of INDIA 6242-P66/RGCB/PMD/DBT/ARVM/2015Tata Memorial Centre IEC/0714/001
6 · The paper itself

Abstract

purposeHeterogeneity within GBMs and variability of visualized fluorescence combine to confer practical limitations to the technique of optical imaging. A biometric analysis was planned to objectively ascertain and analyse this phenomenon

methods25 adult glioblastoma subjects undergoing resection were prospectively accrued. Biopsies were taken from various parts of the tumor and safe peritumoral zones. White light (WL) and visualized fluorescence was subjectively recorded. Corresponding histopathology [coalescent (C) or infiltrating (I) tumor] and protoporphyrin-IX (PPIX) levels were assayed.

resultsWL was very sensitive for detecting tumor. SF was more specific and had high positive predictive value for detecting tumor. WF on the other hand had a poor discriminatory efficacy. Mean PPIX levels were 3.0, 2.01 and 0.16 for SF, WF, and NF respectively. WF had a wide variable range of PPIX levels. Within the coalescent tumor areas, there was a variable distribution of fluorescence (both subjective as well as objective PPIX levels) with only 54% samples showing SF and high PPIX. In seven cases this discordance was noted within the same tumor (biological heterogeneity).

conclusionsFluorescence may miss important tumor areas even if objective assessment is used. Histologically similar tumor areas may exhibit contrasting fluorescence properties, a phenomenon which needs further investigation and elucidation of underlying mechanisms which could potentially be manipulated to optimize the utility of fluorescence guidance.

Indexed as

Brain NeoplasmsGlioblastomaHumansOptical ImagingProspective StudiesProtoporphyrinsSensitivity and Specificityprotoporphyrin IXProtoporphyrinsBiological heterogeneityDiagnostic accuracyFluorescenceGlioblastomaIntratumoral heterogeneityProtoporphyrin

Identifiers

PMID32020478
OpenAlexW3005031396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.