ArticleBreast cancer research and treatment2020
Accelerated aging in breast cancer survivors and its association with mortality and cancer recurrence.
Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The RESILIENT Study: A Retrospective, Descriptive, Correlational Investigation of Correlates of Oral Endocrine Therapy Adherence in Older Women With Breast Cancer.Cancer medicine · 2026Article
- Combined association between phenotypic age acceleration and dietary fiber intake with mortality in middle-aged and elderly cancer survivors.Nutrition journal · 2025Article
- Fatigue in long-term cancer survivors: prevalence, associated factors, and mortality. A prospective population-based study.British journal of cancer · 2025Article
- Digitally Mediated Occupational Therapy to Increase Physical Activity in Urban and Rural Breast Cancer Survivors: Protocol for a Single-Arm Feasibility Trial.JMIR research protocols · 2025Article
- Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers.Cancer medicine · 2025Review
- Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors.Aging · 2025Article
- Current Evidence on the Impact of Diet, Food, and Supplement Intake on Breast Cancer Health Outcomes in Patients Undergoing Endocrine Therapy.Nutrients · 2025Review
- An Aging-Related lncRNA Signature Establishing for Breast Cancer Prognosis and Immunotherapy Responsiveness Prediction.Pharmacogenomics and personalized medicine · 2024Article
- The relationship between unmet cancer care needs and self-rated health among adolescents and young adults with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Premature aging in childhood cancer survivors.Oncology letters · 2023Review
- Psychological measures of stress and biomarkers of inflammation, aging, and endothelial dysfunction in breast cancer survivors on aromatase inhibitors.Scientific reports · 2023Article
- Weight perception and self-rated health: are there differences between cancer survivors and non-cancer survivors?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Survivors' health competence mediates the association between wearable activity tracker use and self-rated health: HINTS analysis.Journal of cancer survivorship : research and practice · 2022Article
- Senescence and cancer - role and therapeutic opportunities.Nature reviews. Clinical oncology · 2022Review
- Cancer and aging: A call to action.Aging and cancer · 2022Article
- Trajectories of objectively measured physical function among older breast cancer survivors in comparison with cancer-free controls.Breast cancer research and treatment · 2022Article
- Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Prediction of all-cause mortality from 24 month trajectories in patient-reported psychological, clinical and quality of life outcomes in uveal melanoma patients.Journal of behavioral medicine · 2022Article
- Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche.Frontiers in cell and developmental biology · 2022Review
- Correlation Analysis of Pathological Features and Axillary Lymph Node Metastasis in Patients with Invasive Breast Cancer.Journal of immunology research · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo prospectively investigate accelerated aging and its association with total mortality and breast cancer-specific mortality/recurrence among breast cancer survivors.
methodsThis study included 4218 female breast cancer patients enrolled into a population-based cohort study approximately 6-month post-diagnosis. Information on aging-related symptoms (i.e., self-rated overall health condition, energy level, depression, sleep difficulty, and quality) was collected at 18- and 36-month post-diagnosis surveys. Information on overall health, daily function impairments, survival status, and recurrence was collected at 10-year post-diagnosis survey. Record linkages with vital statistics were conducted to collect mortality information. Cox proportional hazards model was applied.
resultsAmong 3041 10-year survivors with a mean age of 63.7 ± 9.7 years, respectively, 52.3%, 19.0%, and 27.6% reported poor health, limitation in daily activity, and climbing floors. Age-specific prevalence revealed that breast cancer survivors reached similar prevalence of the functional limitations 5-10 years earlier than cancer-free women. At the 18-month post-diagnosis survey, respectively, 47.0%, 72.5%, and 25.1% of survivors reported unsatisfied overall health condition, reduced energy level, and depression symptoms. After a median follow-up of 10.9 years, low self-rated overall health, low energy level, and depression were significantly associated with increased total mortality, with hazard ratios (HRs; 95% confidence intervals [CI]) of 3.14 (2.43, 4.06), 1.49 (1.20, 1.84), and 1.59 (1.21, 2.09), respectively. Low self-rated health was associated with breast cancer-specific mortality/recurrence (HR 1.85, 95% CI 1.30, 2.65). No significant association was found for sleep difficulty and quality.
conclusionAging-related physical changes/symptoms are commonly presented at 18 months after breast cancer diagnosis and are associated with worse prognosis. IMPACT: Our findings highlight the concern of accelerated aging among breast cancer survivors.
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