Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Exercise is more effective than health education in reducing fatigue in fatigued cancer survivors.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Updated systematic review and meta-analysis: taking the next step in physical activity behavioral interventions for post-treatment breast cancer survivors.Breast cancer research and treatment · 2026Pooled it
- Effects of exercise interventions on sleep quality in breast cancer survivors: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Interventions to reduce kinesiophobia in breast cancer patients: a systematic review.BMC women's health · 2025Pooled it
- The effect of exercise on cognitive function in breast cancer survivors: systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Exercise to Manage Fatigue During and After Chemotherapy in Adolescents and Young Adults With Cancer: A Systematic Review and Meta-Analysis.Oncology nursing forum · 2025Pooled it
- The effect of psychologically informed practice with behavioural graded activity in cancer survivors: systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2024Pooled it
- Trial
- Trial
- Management of fatigue in gynaecological cancer: A feasibility study of an app-based exercise and mindfulness intervention.Gynecologic oncology reports · 2025Article
- Exercise Intervention on Insomnia in Patients with a Cancer: A Systematic Review of the Literature.Cancers · 2024Review
- Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Article
- Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study.Physical therapy · 2022Observational
- Self-managed physical activity in cancer survivors for the management of cancer-related fatigue: A scoping review.PloS one · 2022Article
- Fatigue and functional outcomes in cancer rehabilitation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy.Molecular therapy. Nucleic acids · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionCancer-related fatigue is a most debilitating side effect reported by survivors, often lasting years following treatment. PURPOSE: To determine the effects of a 10-week exercise intervention compared with a health education intervention on fatigue, quality of life outcomes and functional fitness in cancer survivors with documented fatigue.
methodsThis quasi-experimental study allocated 37 post-treatment fatigued cancer survivors (33 female, 30 breast cancer, aged 55 ± 2 years, time since treatment 2.3 ± 0.3 years; mean ± SEM) to an exercise group (EX, n = 19) or health education comparison group (HE, n = 18). The EX intervention emphasised brisk walking with progressive increments, stretching, exercise education and self-efficacy enhancement. The HE intervention emphasised sleep management, nutrition and cognitive behavioural therapy. All participants were evaluated at pre- and post-intervention with EX followed up at 26 W.
resultsThe intervention effect on fatigue (FACT-F) in EX was greater (p < 0.05) than that in HE, the difference being 4 times the recognised clinically important difference. The intervention also increased (p < 0.05) cognitive function, global quality of life and functional fitness scores. It reduced (p < 0.05) insomnia and fear of physical activity. All intervention effects were maintained to 26 W. The intervention effect on fatigue in EX was largely achieved by week 4. There was 100% retention rate at 10 W and no adverse events reported.
conclusionsThere is a reduction of considerable magnitude in cancer fatigue from group-based exercise training, that is sustainable and attributable to exercise per se. IMPLICATIONS FOR CANCER SURVIVORS: Exercise training is feasible for fatigued cancer survivors and should form part of tailored rehabilitation programmes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.